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Immunohistochemical expression of epidermal growth factor receptor in human colorectal adenocarcinoma : a clinicopathological study
Joint Authors
al-Khafaji, Khitam R.
al-Atrushi, Sazan A. Mirza
Abd al-Ghafur, Kifah H.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 58, Issue 1 (31 Mar. 2016), pp.58-62, 5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2016-03-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
Background : Colorectal Adenocarcinoma contributes one of the most common malignancies and the second leading cause of death from cancer in the western world.
Epidermal growth factor receptor (EGFR) belongs to a family (ErbB-tyrosine receptors), EGFR plays an important role in the pathogenesis of colorectal cancer.
Objectives : to evaluate the immunohistochemical expression of epidermal growth factor receptors (EGFR) in colorectal adenocarcinoma and to correlate this expression with different clinicopathological parameters.
Pateints and method : In this study clinicopathological parameters of twenty five colorectal adenocarcinoma cases diagnosed in private pathology laboratories in Baghdad /Iraq from November 2012 to September 2013 were respectively evaluated in terms of age, gender, pathological diagnosis including; tumor location, lymph node status.
EGFR expression was investigated immunohistochemically.
Results : twenty five colorectal cancer patients were included in this study with median age 54.5, range from (28-81)years, 15 cases (60%) were female and 10 (40%) cases were male.
Tumor size range from 3-10 cm with mean 6.5 cm, 10 (40%) cases were from rectum, 7 (28%) from the right side colon & 8 (32%) cases were from from left side colon.
Twenty three (92%) cases were moderately differentiated, and two (8%) cases were poorly differentiated, five (20%) cases were T1, 10 (40%) cases were T2, 5 (20%) cases were each T3 & T4 respectively.
3 (12%) cases were N1, 7 (28%) cases were N2, and fifteen (60%) cases have no lymph node involvement.
Three (12%) cases with distant metastasis.
Eighteen (72%) cases of colorectal adenocarcinoma demonstrate EGFR reactivity in > 1% of the tumor cells.
No significant statistical correlation was noticed between EGFR expression and each of age, gender, site of the tumor and grade of tumor (P value > 0.05).
A significant statistical correlation was noted between EGFR expression and local tumor invasion (T) and lymph node involvement (p value <0.05).
Conclusion : Epidermal growth factor receptor plays an important role in colorectal adenocarcinoma oncogenesis.
EGFR expression appears to have a value as a prognostic biomarker, since it’s expression by the tumor cells is significantly correlated to lymph node involvement and tumor local invasion.
American Psychological Association (APA)
Abd al-Ghafur, Kifah H.& al-Khafaji, Khitam R.& al-Atrushi, Sazan A. Mirza. 2016. Immunohistochemical expression of epidermal growth factor receptor in human colorectal adenocarcinoma : a clinicopathological study. Journal of the Faculty of Medicine Baghdad،Vol. 58, no. 1, pp.58-62.
https://search.emarefa.net/detail/BIM-685268
Modern Language Association (MLA)
Abd al-Ghafur, Kifah H.…[et al.]. Immunohistochemical expression of epidermal growth factor receptor in human colorectal adenocarcinoma : a clinicopathological study. Journal of the Faculty of Medicine Baghdad Vol. 58, no. 1 (2016), pp.58-62.
https://search.emarefa.net/detail/BIM-685268
American Medical Association (AMA)
Abd al-Ghafur, Kifah H.& al-Khafaji, Khitam R.& al-Atrushi, Sazan A. Mirza. Immunohistochemical expression of epidermal growth factor receptor in human colorectal adenocarcinoma : a clinicopathological study. Journal of the Faculty of Medicine Baghdad. 2016. Vol. 58, no. 1, pp.58-62.
https://search.emarefa.net/detail/BIM-685268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 61-62
Record ID
BIM-685268