Hepatic and renal toxicity of methamidophos in male domestic rabbit
العناوين الأخرى
أثر سمية التمارون علي الكبد و الكلية في ذكور الأرانب المحلية
مقدم أطروحة جامعية
al-Najjar, Muhammad Samir Shahdah
مشرف أطروحة جامعية
أعضاء اللجنة
al-Habibi, Mahmud Ismail
al-Nabris, Kamal Jad Allah
الجامعة
الجامعة الإسلامية
الكلية
كلية العلوم
القسم الأكاديمي
قسم العلوم الحياتية
دولة الجامعة
فلسطين (قطاع غزة)
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2015
الملخص الإنجليزي
Objective: The present study is aimed to investigate hepatic and renal toxicity of methamidophos in male domestic rabbit.
Materials and Methods: The oral LD50 of methamidophos in male domestic rabbit was calculated and found to be 20.5 mg kg-1 body weight.
The daily dose of 1/10 LD50 methamidophos (2.1 mg kg-1 body weight) was given orally to 36 animals under experiment for six weeks.
Thirty six control animals were given distilled water.
Blood samples were collected weekly and analyzed.
Results: The overall mortality rate was 11.1% in methamidophos-treated rabbits compared to 0.0% in controls.
Clinical signs included diarrhea, disorientation, drowsiness, weakness, depression and mild tremors.
The final body weight was significantly decreased in methamidophos-intoxicated rabbits.
Serum glucose was significantly increased in response to methamidophos administration recording a maximum percentage difference of 27.1% in the 4th week of the experiment.
The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (γ- GT) were significantly higher in methamidophos-fed rabbits compared to controls, registering maximum percentage differences of 31.2, 44.7, 26.7 and 45.6% during the 6th, 4th, 4th and 3rd weeks of the experiment.
In contrast, serum cholinesterase (ChE) was significantly decreased recording a maximum percentage difference of 77.8% at the end of the experiment.
Serum bilirubin was gradually increased to record a maximum percentage difference of 19.3% in the 5th week.
Serum urea and creatinine concentrations were significantly elevated in response to methamidophos intake displaying maximum percentage differences of 45.8% and 31.7% during the 4th week of the experiment.
Serum total protein, albumin and globulin were significantly decreased upon methamidophos intoxication exhibiting percentage differences of 27.0, 25.9 and 24.3% at 5th week of the experiment.
Serum calcium was significantly decreased in methamidophos-treated rabbits with a maximum percentage difference of 17.4% at the end of the experiment, whereas phosphorus was significantly increased with a maximum percentage difference of 23.8% at the 4th week of the experiment.
Conclusions: Oral daily administration of 1/10 LD50 methamidophos caused significant decrease in the body weight, serum cholinesterase, total protein, albumin, globulin and calcium whereas serum glucose, ALT, AST, ALP, -GT, bilirubin, urea, creatinine and phosphorus were significantly increased.
التخصصات الرئيسية
الموضوعات
عدد الصفحات
59
قائمة المحتويات
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Materials and methods.
Chapter Four : Results.
Chapter Five : Discussion.
Chapter Six : Conclusion.
References.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Najjar, Muhammad Samir Shahdah. (2015). Hepatic and renal toxicity of methamidophos in male domestic rabbit. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-687997
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Najjar, Muhammad Samir Shahdah. Hepatic and renal toxicity of methamidophos in male domestic rabbit. (Master's theses Theses and Dissertations Master). Islamic University. (2015).
https://search.emarefa.net/detail/BIM-687997
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Najjar, Muhammad Samir Shahdah. (2015). Hepatic and renal toxicity of methamidophos in male domestic rabbit. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-687997
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-687997
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر