Effect of crempphor- el on cisplatin- induced organ toxity in nor-mal rat
المؤلفون المشاركون
Sayyid-Ahmad, Muhammad M.
Arafah, Husam M.
Ramadan, Layla A.
al-Habit, Ula Hassan
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 13، العدد 2 (30 يونيو/حزيران 2001)، ص ص. 139-145، 7ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2001-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Cisplatin in an inorganic platinum compound with a broad spectrum antineoplastic activity against different types of tumours.
Pharmacological and cytogenetic evaluations of the possible protective effects of cremophor-EL (cremophor) against cisplatin-induced nephro-, hepato-and bone marrow toxicity in normal rats were carried out.
A single dose of cisplatin (7.5 mg / kg i.v.) caused acute nephrotoxicity biochemically manifested as an increase in serum urea nitrogen (528 %) and serum creatinine (1307 %).
Serum alanine and aspartate aminotransferase levels were also increased.
In the liver tissue, glutathione level (GSH) decreased significantly 7 days after cisplatin treatment.
Cisplatin caused a significant increase in the frequency of micronuclei (MN) of polychromatic eryth-rocytes (PCEs) and norm chromatic erythrocytes (NCEs), as well as the ratio of PCEs/NCEs.
Moreover, a significant delay in the mitotic activity was observed after cisplatin treatment.
Administration of cremophor at a dose of 50 µl/ kg intravenously 5 minutes before cisplatin protected the kidney and liver as indicated by restoration of urea and cretonne concentrations, as well as aminotransferase activities.
Pretreatment with cremophor resulted in a significant recovery in the frequency of cisplatin-induced increase in MV, in the ratio of PCEs / NCEs, as well as in the MI of bone marrow.
Administration of cremophor before cisplatin did not interfere with the antitumour activity of cisplatin in EAC-bearing mice.
These results suggest that cremophor administration may play a role to prevent cis-platin-induced damage to the kidney, liver and bone marrow without interfering with its antitumour activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramadan, Layla A.& al-Habit, Ula Hassan& Arafah, Husam M.& Sayyid-Ahmad, Muhammad M.. 2001. Effect of crempphor- el on cisplatin- induced organ toxity in nor-mal rat. Journal of the Egyptian National Cancer Institute،Vol. 13, no. 2, pp.139-145.
https://search.emarefa.net/detail/BIM-69203
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramadan, Layla A.…[et al.]. Effect of crempphor- el on cisplatin- induced organ toxity in nor-mal rat. Journal of the Egyptian National Cancer Institute Vol. 13, no. 2 (Jun. 2001), pp.139-145.
https://search.emarefa.net/detail/BIM-69203
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramadan, Layla A.& al-Habit, Ula Hassan& Arafah, Husam M.& Sayyid-Ahmad, Muhammad M.. Effect of crempphor- el on cisplatin- induced organ toxity in nor-mal rat. Journal of the Egyptian National Cancer Institute. 2001. Vol. 13, no. 2, pp.139-145.
https://search.emarefa.net/detail/BIM-69203
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 143-145
رقم السجل
BIM-69203
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر