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Effect of crempphor- el on cisplatin- induced organ toxity in nor-mal rat
Joint Authors
Sayyid-Ahmad, Muhammad M.
Arafah, Husam M.
Ramadan, Layla A.
al-Habit, Ula Hassan
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 13, Issue 2 (30 Jun. 2001), pp.139-145, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2001-06-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Cisplatin in an inorganic platinum compound with a broad spectrum antineoplastic activity against different types of tumours.
Pharmacological and cytogenetic evaluations of the possible protective effects of cremophor-EL (cremophor) against cisplatin-induced nephro-, hepato-and bone marrow toxicity in normal rats were carried out.
A single dose of cisplatin (7.5 mg / kg i.v.) caused acute nephrotoxicity biochemically manifested as an increase in serum urea nitrogen (528 %) and serum creatinine (1307 %).
Serum alanine and aspartate aminotransferase levels were also increased.
In the liver tissue, glutathione level (GSH) decreased significantly 7 days after cisplatin treatment.
Cisplatin caused a significant increase in the frequency of micronuclei (MN) of polychromatic eryth-rocytes (PCEs) and norm chromatic erythrocytes (NCEs), as well as the ratio of PCEs/NCEs.
Moreover, a significant delay in the mitotic activity was observed after cisplatin treatment.
Administration of cremophor at a dose of 50 µl/ kg intravenously 5 minutes before cisplatin protected the kidney and liver as indicated by restoration of urea and cretonne concentrations, as well as aminotransferase activities.
Pretreatment with cremophor resulted in a significant recovery in the frequency of cisplatin-induced increase in MV, in the ratio of PCEs / NCEs, as well as in the MI of bone marrow.
Administration of cremophor before cisplatin did not interfere with the antitumour activity of cisplatin in EAC-bearing mice.
These results suggest that cremophor administration may play a role to prevent cis-platin-induced damage to the kidney, liver and bone marrow without interfering with its antitumour activity.
American Psychological Association (APA)
Ramadan, Layla A.& al-Habit, Ula Hassan& Arafah, Husam M.& Sayyid-Ahmad, Muhammad M.. 2001. Effect of crempphor- el on cisplatin- induced organ toxity in nor-mal rat. Journal of the Egyptian National Cancer Institute،Vol. 13, no. 2, pp.139-145.
https://search.emarefa.net/detail/BIM-69203
Modern Language Association (MLA)
Ramadan, Layla A.…[et al.]. Effect of crempphor- el on cisplatin- induced organ toxity in nor-mal rat. Journal of the Egyptian National Cancer Institute Vol. 13, no. 2 (Jun. 2001), pp.139-145.
https://search.emarefa.net/detail/BIM-69203
American Medical Association (AMA)
Ramadan, Layla A.& al-Habit, Ula Hassan& Arafah, Husam M.& Sayyid-Ahmad, Muhammad M.. Effect of crempphor- el on cisplatin- induced organ toxity in nor-mal rat. Journal of the Egyptian National Cancer Institute. 2001. Vol. 13, no. 2, pp.139-145.
https://search.emarefa.net/detail/BIM-69203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 143-145
Record ID
BIM-69203