Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy
المؤلفون المشاركون
Nasir al-Din, Muhammad
Khan, Irfan Ahmad
Haque, Shahzad F.
Khan, Rahat A.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 27، العدد 4 (31 أغسطس/آب 2016)، ص ص. 710-716، 7ص.
الناشر
تاريخ النشر
2016-08-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
- المرضى
- الأحماض العضوية
- الأحماض الأمينية
- المركبات الأمينية
- اعتلال الكلى السكري
- الهند
- الأحماض الكيتونية
- راوند(نبات)
- التشخيص
- الجوانب الجزيئية
الملخص EN
To determine the efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients of diabetic nephropathy (DN), we studied 96 patients of DN attending a tertiary care center of the North India.
The patients were randomly divided into three equal interventional groups.
Group I (control) that received conservative management along with placebo, Group II (rhubarb) that received conservative management along with rhubarb capsule (350 mg, thrice daily), and Group III [keto amino acid (KAA)] that received conservative management along with α-keto analogs of essential amino acids (600 mg, thrice daily).
The treatment was continued for 12 weeks.
Clinical and biochemical parameters were assessed at 0, 4, 8, and 12 weeks of treatment.
A progressive improvement in clinical features and biochemical parameters was seen in all three groups after 12 weeks of treatment.
The KAA group showed more marked improvement in clinical features as well as biochemical parameters compared to the rhubarb group.
There was a reduction in blood glucose, blood urea, serum creatinine, and 24 h total urine protein.
There was an increase in hemoglobin, 24 h total urine volume, and glomerular filtration rate.
There was no statistical difference between the rhubarb and KAA groups with respect to side effects (P > 0.05).
Our study suggests that KAA is more effective than rhubarb as add-on therapy with conservative management in patients of DN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Irfan Ahmad& Nasir al-Din, Muhammad& Haque, Shahzad F.& Khan, Rahat A.. 2016. Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 4, pp.710-716.
https://search.emarefa.net/detail/BIM-693075
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Irfan Ahmad…[et al.]. Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 4 (Jul. / Aug. 2016), pp.710-716.
https://search.emarefa.net/detail/BIM-693075
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Irfan Ahmad& Nasir al-Din, Muhammad& Haque, Shahzad F.& Khan, Rahat A.. Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 4, pp.710-716.
https://search.emarefa.net/detail/BIM-693075
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 715-716
رقم السجل
BIM-693075
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر