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Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy
Joint Authors
Nasir al-Din, Muhammad
Khan, Irfan Ahmad
Haque, Shahzad F.
Khan, Rahat A.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 4 (31 Aug. 2016), pp.710-716, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-08-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
- Patients
- Organic acids
- Amino acids
- Amino compounds
- Diabetic nephropathies
- India
- Ketonic acids
- Rheum
- Diagnosis
- Molecular aspects
Abstract EN
To determine the efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients of diabetic nephropathy (DN), we studied 96 patients of DN attending a tertiary care center of the North India.
The patients were randomly divided into three equal interventional groups.
Group I (control) that received conservative management along with placebo, Group II (rhubarb) that received conservative management along with rhubarb capsule (350 mg, thrice daily), and Group III [keto amino acid (KAA)] that received conservative management along with α-keto analogs of essential amino acids (600 mg, thrice daily).
The treatment was continued for 12 weeks.
Clinical and biochemical parameters were assessed at 0, 4, 8, and 12 weeks of treatment.
A progressive improvement in clinical features and biochemical parameters was seen in all three groups after 12 weeks of treatment.
The KAA group showed more marked improvement in clinical features as well as biochemical parameters compared to the rhubarb group.
There was a reduction in blood glucose, blood urea, serum creatinine, and 24 h total urine protein.
There was an increase in hemoglobin, 24 h total urine volume, and glomerular filtration rate.
There was no statistical difference between the rhubarb and KAA groups with respect to side effects (P > 0.05).
Our study suggests that KAA is more effective than rhubarb as add-on therapy with conservative management in patients of DN.
American Psychological Association (APA)
Khan, Irfan Ahmad& Nasir al-Din, Muhammad& Haque, Shahzad F.& Khan, Rahat A.. 2016. Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 4, pp.710-716.
https://search.emarefa.net/detail/BIM-693075
Modern Language Association (MLA)
Khan, Irfan Ahmad…[et al.]. Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 4 (Jul. / Aug. 2016), pp.710-716.
https://search.emarefa.net/detail/BIM-693075
American Medical Association (AMA)
Khan, Irfan Ahmad& Nasir al-Din, Muhammad& Haque, Shahzad F.& Khan, Rahat A.. Comparative evaluation of efficacy and safety profile of rhubarb and α-keto analogs of essential amino acids supplementation in patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 4, pp.710-716.
https://search.emarefa.net/detail/BIM-693075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 715-716
Record ID
BIM-693075