![](/images/graphics-bg.png)
Mycophenolate mofetil versus azathioprine for maintenance treatment of lupus nephritis
المؤلفون المشاركون
Ahmad, Ahmad Ilyas
Nur, Musa Muhammad
Khalid, Ismail Uthman
Abu Ayshah, Hasan
Kaballo, Babikir Jabir
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 27، العدد 4 (31 أغسطس/آب 2016)، ص ص. 717-725، 9ص.
الناشر
تاريخ النشر
2016-08-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
To compare the efficacy of mycophenolate mofetil (MMF) with that of azathioprine (AZA) drugs in the maintenance therapy of lupus nephritis (LN) patients, we studied 81 Sudanese patients with LN (32 in Class III, 34 in Class IV, and 15 in combined Class V + IV of the ISN/RPS 2003 Classification).
All patients received induction therapy consisting of monthly intravenous pulse doses of cyclophosphamide (CYC) (500 mg/m2 of body-surface area) for six months, plus three consecutive pulses of intravenous methylprednisolone 15 mg/kg/day of body weight (maximum 500 mg).
Subsequently, 41 (50.6%) patients were randomized into a group that received oral MMF (22 mg/kg/day), and 40 (49.4%) patients randomized to a group that received oral AZA (2 mg/kg/day).
All patients initially received oral prednisone (1 mg/kg of body weight daily) for four weeks.
The baseline characteristics of the two groups were similar.
Total remission rate was 75.3% (80.5% in MMF and 70% in AZA), complete remission rate of 54.3% (56.1% with MMF and 52.5% with AZA), and a partial remission rate of 21% (24.4% with MMF and 17.5% with AZA) over 29 months.
During maintenance therapy, six patients died (four in the AZA group and two in the MMF group), and end-stage renal disease (ESRD) developed in five patients (three in the AZA group and two in the MMF group).
During the 36-months of the study, both groups had comparable event-free survival rate for the composite end point of death or ESRD and rate of relapse-free survival.
Furthermore, both groups had no significant differences in terms of frequency of hospitalization, amenorrhea, infection, nausea, and vomiting.
We conclude.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kaballo, Babikir Jabir& Ahmad, Ahmad Ilyas& Nur, Musa Muhammad& Khalid, Ismail Uthman& Abu Ayshah, Hasan. 2016. Mycophenolate mofetil versus azathioprine for maintenance treatment of lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 4, pp.717-725.
https://search.emarefa.net/detail/BIM-693079
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kaballo, Babikir Jabir…[et al.]. Mycophenolate mofetil versus azathioprine for maintenance treatment of lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 4 (Jul. / Aug. 2016), pp.717-725.
https://search.emarefa.net/detail/BIM-693079
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kaballo, Babikir Jabir& Ahmad, Ahmad Ilyas& Nur, Musa Muhammad& Khalid, Ismail Uthman& Abu Ayshah, Hasan. Mycophenolate mofetil versus azathioprine for maintenance treatment of lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 4, pp.717-725.
https://search.emarefa.net/detail/BIM-693079
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 724-725
رقم السجل
BIM-693079
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)