Mycophenolate mofetil versus azathioprine for maintenance treatment of lupus nephritis
Joint Authors
Ahmad, Ahmad Ilyas
Nur, Musa Muhammad
Khalid, Ismail Uthman
Abu Ayshah, Hasan
Kaballo, Babikir Jabir
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 4 (31 Aug. 2016), pp.717-725, 9 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-08-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
To compare the efficacy of mycophenolate mofetil (MMF) with that of azathioprine (AZA) drugs in the maintenance therapy of lupus nephritis (LN) patients, we studied 81 Sudanese patients with LN (32 in Class III, 34 in Class IV, and 15 in combined Class V + IV of the ISN/RPS 2003 Classification).
All patients received induction therapy consisting of monthly intravenous pulse doses of cyclophosphamide (CYC) (500 mg/m2 of body-surface area) for six months, plus three consecutive pulses of intravenous methylprednisolone 15 mg/kg/day of body weight (maximum 500 mg).
Subsequently, 41 (50.6%) patients were randomized into a group that received oral MMF (22 mg/kg/day), and 40 (49.4%) patients randomized to a group that received oral AZA (2 mg/kg/day).
All patients initially received oral prednisone (1 mg/kg of body weight daily) for four weeks.
The baseline characteristics of the two groups were similar.
Total remission rate was 75.3% (80.5% in MMF and 70% in AZA), complete remission rate of 54.3% (56.1% with MMF and 52.5% with AZA), and a partial remission rate of 21% (24.4% with MMF and 17.5% with AZA) over 29 months.
During maintenance therapy, six patients died (four in the AZA group and two in the MMF group), and end-stage renal disease (ESRD) developed in five patients (three in the AZA group and two in the MMF group).
During the 36-months of the study, both groups had comparable event-free survival rate for the composite end point of death or ESRD and rate of relapse-free survival.
Furthermore, both groups had no significant differences in terms of frequency of hospitalization, amenorrhea, infection, nausea, and vomiting.
We conclude.
American Psychological Association (APA)
Kaballo, Babikir Jabir& Ahmad, Ahmad Ilyas& Nur, Musa Muhammad& Khalid, Ismail Uthman& Abu Ayshah, Hasan. 2016. Mycophenolate mofetil versus azathioprine for maintenance treatment of lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 4, pp.717-725.
https://search.emarefa.net/detail/BIM-693079
Modern Language Association (MLA)
Kaballo, Babikir Jabir…[et al.]. Mycophenolate mofetil versus azathioprine for maintenance treatment of lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 4 (Jul. / Aug. 2016), pp.717-725.
https://search.emarefa.net/detail/BIM-693079
American Medical Association (AMA)
Kaballo, Babikir Jabir& Ahmad, Ahmad Ilyas& Nur, Musa Muhammad& Khalid, Ismail Uthman& Abu Ayshah, Hasan. Mycophenolate mofetil versus azathioprine for maintenance treatment of lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 4, pp.717-725.
https://search.emarefa.net/detail/BIM-693079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 724-725
Record ID
BIM-693079