![](/images/graphics-bg.png)
The relationship between coronary artery disease and genetic polymorphisms of proprotein convertase Subtilisin Kexin type 9
المؤلفون المشاركون
Zaimkohan, Hooshang
Keramatipour, Muhammad
Mirhafez, Seyed Reza
Bazzaz, Javad Tavakkoly
Tahooni, Azadeh
Piryaei, Muhammad
Ghaderian, Seyed Muhammad Husayn
Ghayour Mobarhan, Majid
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 18، العدد 5 (31 مايو/أيار 2016)، ص ص. 1-4، 4ص.
الناشر
تاريخ النشر
2016-05-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates the plasma level of LDL cholesterol.
The R46L single-nucleotide polymorphism of the PCSK9 gene has been reported to be associated with serum LDL concentrations and reduced risk of coronary artery disease (CAD).
However, there have been no studies analyzing the association of this polymorphism with CAD in Iranian individuals with CAD.
Objectives: Therefore, in the present study we have investigated the potential protective effect of the rs11591147 PCSK9 polymorphism in 188 subjects with and without CAD.
Materials and Methods: Genotyping of the PCSK9 gene was undertaken using TaqMan real-time PCR in all subjects.
Anthropometric and biochemical features, including HDL, LDL, and TG were assessed in all subjects.
Results: The CAD patients had significantly (P < 0.05) higher BMI and significantly higher levels of TG, LDL, SBP, and DBP, while the level of HDL was lower compared to that of the control group.
R46L was not associated with CAD in our population sample.
Conclusions: The PCSK9-R46L polymorphism is unlikely to play an important role in CAD in the Iranian population.
However, further studies are needed in a larger population to confirm this.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Keramatipour, Muhammad& Zaimkohan, Hooshang& Mirhafez, Seyed Reza& Bazzaz, Javad Tavakkoly& Tahooni, Azadeh& Piryaei, Muhammad…[et al.]. 2016. The relationship between coronary artery disease and genetic polymorphisms of proprotein convertase Subtilisin Kexin type 9. Iranian Red Crescent Medical Journal،Vol. 18, no. 5, pp.1-4.
https://search.emarefa.net/detail/BIM-694789
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zaimkohan, Hooshang…[et al.]. The relationship between coronary artery disease and genetic polymorphisms of proprotein convertase Subtilisin Kexin type 9. Iranian Red Crescent Medical Journal Vol. 18, no. 5 (May. 2016), pp.1-4.
https://search.emarefa.net/detail/BIM-694789
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Keramatipour, Muhammad& Zaimkohan, Hooshang& Mirhafez, Seyed Reza& Bazzaz, Javad Tavakkoly& Tahooni, Azadeh& Piryaei, Muhammad…[et al.]. The relationship between coronary artery disease and genetic polymorphisms of proprotein convertase Subtilisin Kexin type 9. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 5, pp.1-4.
https://search.emarefa.net/detail/BIM-694789
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 3-4
رقم السجل
BIM-694789
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)