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The relationship between coronary artery disease and genetic polymorphisms of proprotein convertase Subtilisin Kexin type 9
Joint Authors
Zaimkohan, Hooshang
Keramatipour, Muhammad
Mirhafez, Seyed Reza
Bazzaz, Javad Tavakkoly
Tahooni, Azadeh
Piryaei, Muhammad
Ghaderian, Seyed Muhammad Husayn
Ghayour Mobarhan, Majid
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 5 (31 May. 2016), pp.1-4, 4 p.
Publisher
Publication Date
2016-05-31
Country of Publication
United Arab Emirates
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates the plasma level of LDL cholesterol.
The R46L single-nucleotide polymorphism of the PCSK9 gene has been reported to be associated with serum LDL concentrations and reduced risk of coronary artery disease (CAD).
However, there have been no studies analyzing the association of this polymorphism with CAD in Iranian individuals with CAD.
Objectives: Therefore, in the present study we have investigated the potential protective effect of the rs11591147 PCSK9 polymorphism in 188 subjects with and without CAD.
Materials and Methods: Genotyping of the PCSK9 gene was undertaken using TaqMan real-time PCR in all subjects.
Anthropometric and biochemical features, including HDL, LDL, and TG were assessed in all subjects.
Results: The CAD patients had significantly (P < 0.05) higher BMI and significantly higher levels of TG, LDL, SBP, and DBP, while the level of HDL was lower compared to that of the control group.
R46L was not associated with CAD in our population sample.
Conclusions: The PCSK9-R46L polymorphism is unlikely to play an important role in CAD in the Iranian population.
However, further studies are needed in a larger population to confirm this.
American Psychological Association (APA)
Keramatipour, Muhammad& Zaimkohan, Hooshang& Mirhafez, Seyed Reza& Bazzaz, Javad Tavakkoly& Tahooni, Azadeh& Piryaei, Muhammad…[et al.]. 2016. The relationship between coronary artery disease and genetic polymorphisms of proprotein convertase Subtilisin Kexin type 9. Iranian Red Crescent Medical Journal،Vol. 18, no. 5, pp.1-4.
https://search.emarefa.net/detail/BIM-694789
Modern Language Association (MLA)
Zaimkohan, Hooshang…[et al.]. The relationship between coronary artery disease and genetic polymorphisms of proprotein convertase Subtilisin Kexin type 9. Iranian Red Crescent Medical Journal Vol. 18, no. 5 (May. 2016), pp.1-4.
https://search.emarefa.net/detail/BIM-694789
American Medical Association (AMA)
Keramatipour, Muhammad& Zaimkohan, Hooshang& Mirhafez, Seyed Reza& Bazzaz, Javad Tavakkoly& Tahooni, Azadeh& Piryaei, Muhammad…[et al.]. The relationship between coronary artery disease and genetic polymorphisms of proprotein convertase Subtilisin Kexin type 9. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 5, pp.1-4.
https://search.emarefa.net/detail/BIM-694789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3-4
Record ID
BIM-694789