Association of hla-drb1 alleles and basal cell carcinoma (BCC)‎ of the skin in Basrah

الملخص EN

Immunogenetic factors have been explored as being a possible risk factor in the aetiology of basal cell carcinoma (BCC).

This study aimed to clarify the association of HLA- DRB1 alleles in immunocompetent patients with BCC in Basrah city.

A total of 27 patients with confirmed BCC and 31 controls were analyzed for HLA-DRB1 genotyping using generic SSP2LB one lambda micro ssp- HLA-DNA typing tray.

Results showed a positive association of BCC with HLA DRB1*07 (p-value 0.0280, OR = 3.7143, 95 % CI=1.1521-11.9743), HLA alleles of DRB1*11 (OR = 2.2), DRB1*04(OR = 1.4), DRB1*01(OR = 1.125) have a higher frequency among cases but the association is not significant.

These finding suggest a possible immunogenetic role in the development of BCC.