Synthesis, characterization and biological activity of novel complexes of zinc (II)‎ ibuprofen with nitrogen based ligands

العناوين الأخرى

تحضير، تشخيص و دراسة الفعالية الحيوية لمركبات تحتوي أيون الزنك الثنائي الشحنة و حامض الايبوبروفين مع بعض القواعد النيتروجينية

مقدم أطروحة جامعية

Umar, Suhad Nizar

مشرف أطروحة جامعية

Abu Ali, Hijazi

أعضاء اللجنة

Rappocciolo, Emilia
Hamid, Mazin

الجامعة

جامعة بيرزيت

الكلية

كلية العلوم

القسم الأكاديمي

دائرة الكيماء

دولة الجامعة

فلسطين (الضفة الغربية)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2013

الملخص الإنجليزي

Nine Zn(II) complexes were prepared and characterized.

The synthesis was started by preparation of zinc ibuprofen [Zn2(ibup)4] 1, after that, different nitrogen-donor ligands were reacted with complex 1 to produce the target complexes.

The complexes were [Zn(ibup)2(2-ampy)2] 2, [Zn(ibup)2(2-ammethylpy)2] 3, [Zn(ibup)2(2,2`-bipy)] 4, [Zn(ibup)2(4,4`-bipy)]n 5, [Zn(ibup)2(1,10-phen)] 6, [Zn(ibup)2(2,9-dmphen)] 7, [Zn(ibup)2(1,2-dmimidazole)2] 8 and [Zn(ibup)2(2-am-6-picoline)2] 9.

IR, 1H NMR,13C{1H} NMR and UV-Vis spectrophotometric techniques were used for characterization.

The crystal structures of complexes 2 and 5 were determined by single-crystal X-ray diffraction.

The investigation of in-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis) bacteria was done using agar well-diffusion method.

Complexes 1 and 5 showed anti-bacterial activity against G-positive bacteria.

Complexes 2, 3, 8 and 9 did not exhibit any anti-bacterial activity.

Complexes 4, 6 and 7 showed anti-bacterial activity and were chosen for further studies to determine IZD for different concentrations of each one and to set the MIC for each complex.

The complexation of zinc-ibuprofen with 2,2`-bipy and 1,10-phen in complexes 4 and 6, respectively decreased the anti-bacterial activity against most of the bacteria used.

The complexation in 7 decreased the anti-bacterial activity in Gram-positive bacteria but in case of Gram-negative, the overall anti-bacterial activity of uncoordinated 2,9-dmphen was enhanced on coordination with zinc ibuprofen.

التخصصات الرئيسية

الكيمياء

عدد الصفحات

90

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-706446