Synthesis, characterization and biological activity of novel complexes of zinc (II)‎ ibuprofen with nitrogen based ligands

Other Title(s)

تحضير، تشخيص و دراسة الفعالية الحيوية لمركبات تحتوي أيون الزنك الثنائي الشحنة و حامض الايبوبروفين مع بعض القواعد النيتروجينية

Dissertant

Umar, Suhad Nizar

Thesis advisor

Abu Ali, Hijazi

Comitee Members

Rappocciolo, Emilia
Hamid, Mazin

University

Birzeit University

Faculty

Faculty of Science

Department

Department of Chemistry

University Country

Palestine (West Bank)

Degree

Master

Degree Date

2013

English Abstract

Nine Zn(II) complexes were prepared and characterized.

The synthesis was started by preparation of zinc ibuprofen [Zn2(ibup)4] 1, after that, different nitrogen-donor ligands were reacted with complex 1 to produce the target complexes.

The complexes were [Zn(ibup)2(2-ampy)2] 2, [Zn(ibup)2(2-ammethylpy)2] 3, [Zn(ibup)2(2,2`-bipy)] 4, [Zn(ibup)2(4,4`-bipy)]n 5, [Zn(ibup)2(1,10-phen)] 6, [Zn(ibup)2(2,9-dmphen)] 7, [Zn(ibup)2(1,2-dmimidazole)2] 8 and [Zn(ibup)2(2-am-6-picoline)2] 9.

IR, 1H NMR,13C{1H} NMR and UV-Vis spectrophotometric techniques were used for characterization.

The crystal structures of complexes 2 and 5 were determined by single-crystal X-ray diffraction.

The investigation of in-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis) bacteria was done using agar well-diffusion method.

Complexes 1 and 5 showed anti-bacterial activity against G-positive bacteria.

Complexes 2, 3, 8 and 9 did not exhibit any anti-bacterial activity.

Complexes 4, 6 and 7 showed anti-bacterial activity and were chosen for further studies to determine IZD for different concentrations of each one and to set the MIC for each complex.

The complexation of zinc-ibuprofen with 2,2`-bipy and 1,10-phen in complexes 4 and 6, respectively decreased the anti-bacterial activity against most of the bacteria used.

The complexation in 7 decreased the anti-bacterial activity in Gram-positive bacteria but in case of Gram-negative, the overall anti-bacterial activity of uncoordinated 2,9-dmphen was enhanced on coordination with zinc ibuprofen.

Main Subjects

Chemistry

No. of Pages

90

Table of Contents

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Language

English

Data Type

Arab Theses

Record ID

BIM-706446