Synthesis, characterization and biological activity of novel complexes of zinc (II) ibuprofen with nitrogen based ligands
Other Title(s)
تحضير، تشخيص و دراسة الفعالية الحيوية لمركبات تحتوي أيون الزنك الثنائي الشحنة و حامض الايبوبروفين مع بعض القواعد النيتروجينية
Dissertant
Thesis advisor
Comitee Members
Rappocciolo, Emilia
Hamid, Mazin
University
Birzeit University
Faculty
Faculty of Science
Department
Department of Chemistry
University Country
Palestine (West Bank)
Degree
Master
Degree Date
2013
English Abstract
Nine Zn(II) complexes were prepared and characterized.
The synthesis was started by preparation of zinc ibuprofen [Zn2(ibup)4] 1, after that, different nitrogen-donor ligands were reacted with complex 1 to produce the target complexes.
The complexes were [Zn(ibup)2(2-ampy)2] 2, [Zn(ibup)2(2-ammethylpy)2] 3, [Zn(ibup)2(2,2`-bipy)] 4, [Zn(ibup)2(4,4`-bipy)]n 5, [Zn(ibup)2(1,10-phen)] 6, [Zn(ibup)2(2,9-dmphen)] 7, [Zn(ibup)2(1,2-dmimidazole)2] 8 and [Zn(ibup)2(2-am-6-picoline)2] 9.
IR, 1H NMR,13C{1H} NMR and UV-Vis spectrophotometric techniques were used for characterization.
The crystal structures of complexes 2 and 5 were determined by single-crystal X-ray diffraction.
The investigation of in-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis) bacteria was done using agar well-diffusion method.
Complexes 1 and 5 showed anti-bacterial activity against G-positive bacteria.
Complexes 2, 3, 8 and 9 did not exhibit any anti-bacterial activity.
Complexes 4, 6 and 7 showed anti-bacterial activity and were chosen for further studies to determine IZD for different concentrations of each one and to set the MIC for each complex.
The complexation of zinc-ibuprofen with 2,2`-bipy and 1,10-phen in complexes 4 and 6, respectively decreased the anti-bacterial activity against most of the bacteria used.
The complexation in 7 decreased the anti-bacterial activity in Gram-positive bacteria but in case of Gram-negative, the overall anti-bacterial activity of uncoordinated 2,9-dmphen was enhanced on coordination with zinc ibuprofen.
Main Subjects
No. of Pages
90
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
[Chapter One] : Introduction.
[Chapter Two] : Experimental.
[Chapter Three] : Results and discussion.
[Chapter Four] : Conclusion.
References.
American Psychological Association (APA)
Umar, Suhad Nizar. (2013). Synthesis, characterization and biological activity of novel complexes of zinc (II) ibuprofen with nitrogen based ligands. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-706446
Modern Language Association (MLA)
Umar, Suhad Nizar. Synthesis, characterization and biological activity of novel complexes of zinc (II) ibuprofen with nitrogen based ligands. (Master's theses Theses and Dissertations Master). Birzeit University. (2013).
https://search.emarefa.net/detail/BIM-706446
American Medical Association (AMA)
Umar, Suhad Nizar. (2013). Synthesis, characterization and biological activity of novel complexes of zinc (II) ibuprofen with nitrogen based ligands. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-706446
Language
English
Data Type
Arab Theses
Record ID
BIM-706446