Antiepileptic and anticonvulsant effect of bongardia chrysogonum on pentylenetetrazol-induced kindling in mice

العناوين الأخرى

تقييم مستخلص درنات نبتة عرف الديك كمضاد للصرع في الفئران

مقدم أطروحة جامعية

al-Shahir, Fadwa Thair

مشرف أطروحة جامعية

Abu Hamdah, Sawsan
Abu Rumaylah, Amjad Naji

أعضاء اللجنة

Nusayr, Khawlah Qasim
al-Abd, Wadi Tawfiq

الجامعة

جامعة الإسراء

الكلية

كلية الصيدلة

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2016

الملخص الإنجليزي

Epilepsy is a diverse set of recurrent chronic neurological disorder which causes substantial mortality and morbidity.

Side effects of common drug regimens used in the treatment of epilepsy are high.

Furthermore, high percentage of seizure types are resistant to well-known drug therapies.

Therefore it is necessary to find new antiepileptic therapies with low side effects that can control various seizure types.

In traditional Jordanian folk medicine, Bongardia chrysogonum tubers are used for the treatment of epilepsy.

In this study kindling method using pentylenetetrazole induced seizures was used to investigate BC tubers ability to reduce the severity of seizures induced by PTZ in mice.

Mice were divided into nine groups, each group included 6 mice.

3 groups were treated by BC water extracts with doses of 600, 900 and 1200 mg/kg of body weight followed by a dose of PTZ, 3 groups were treated by ethanol extracts with doses of 600, 900 and 1200 mg/kg of body weight followed by a dose of PTZ, a group treated with valproic acid with a dose of 200 mg/kg of body weight, a group is given distilled water of a dose of 10 ml/kg of body weight followed by a dose of PTZ, a group were given distilled water only with a dose of 10 mg/kg of body weight.

Kindling was performed in 11 doses every other day.

In the first 10 doses, all groups except the negative control groups were given a dose of 40 mg/kg of PTZ after 30 to 60 minutes of treatment with water extract, ethanol extract and valproic acid.

In the 11thdose also called the challenge dose, all groups were given a dose of 75 mg/kg of PTZ 30 to 60 30 to 60 minutes of treatment with water extract, ethanol extract and valproic acid.

The behavior scale is made by monitoring the mice after giving them the PTZ dose.

Results showed that BC tubers have antiepileptic effect with high protection values in the challenge day in dose dependent manner.

Water extract groups showed higher protections than ethanol extract groups.

Statistical analysis showed significant results between BC water extract groups and PTZ group and between BC ethanol extract groups and PTZ group (p< 0.05).

Antiepileptic effect of BC may be reduced to the presence of previously found active constituents in the tubers working by GABA agonist or NMDA antagonist mechanisms.

التخصصات الرئيسية

العلوم الطبية والصيدلة والعلوم الصحية

عدد الصفحات

46

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-707206