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The protective effect of selinium in methotrexate induced nephrotoxicity in Rabbits
المؤلف
المصدر
Journal of Babylon University : Journal of Applied and Pure Sciences
العدد
المجلد 23، العدد 4 (31 ديسمبر/كانون الأول 2015)، ص ص. 1586-1595، 10ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
العراق
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Methotrexate (MTX), a cytotoxic chemotherapeutic agent, is used in the treatment of acute lymphoblastic leukaemia, lymphoma, osteosarcoma, breast cancer, head and neck cancers and also in the therapy of non oncologic disorders such as rheumatic diseases and psoriasis.
The aim of the present study was to examine the protective effect of selenium against the MTX-induced nephrotoxicity.
Materials and Methods: 21 rabbits were used and randomized in to three groups (7 rabbits each) ,all groups were maintained on standard chow diet throughout the experiment (8 weeks).
Group 1 was treated with normal saline water (control), Group 2 with MTX (nephrotoxic) and Group 3 with MTX plus selinium.
Induction of nephrotoxicity was carried out by administration of MTX to the rabbits in a dose of 0.25 mg/kg /day i.m for 8 weeks.
Blood urea and serum creatinin were measured to asses renal function.
Serum MDA levels and SOD activity also performed.
Results: Eight weeks of MTX treatment produced significant changes in renal function markers.
Further it was found that serum MDA levels and SOD activity were significantly increased, while serum GSH levels were significantly decreased.
Adding selinium to MTX was found to produced significant improvement in renal function .
Conclusion: selinium restored the altered renal function and possessed protection to the kidney against MTX induced nephrotoxicity
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sawadi, Asma A.. 2015. The protective effect of selinium in methotrexate induced nephrotoxicity in Rabbits. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 23, no. 4, pp.1586-1595.
https://search.emarefa.net/detail/BIM-707817
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sawadi, Asma A.. The protective effect of selinium in methotrexate induced nephrotoxicity in Rabbits. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 23, no. 4 (2015), pp.1586-1595.
https://search.emarefa.net/detail/BIM-707817
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sawadi, Asma A.. The protective effect of selinium in methotrexate induced nephrotoxicity in Rabbits. Journal of Babylon University : Journal of Applied and Pure Sciences. 2015. Vol. 23, no. 4, pp.1586-1595.
https://search.emarefa.net/detail/BIM-707817
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Text in English ; abstracts in English and Arabic.
رقم السجل
BIM-707817
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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