Novel biomarker in polycystic ovary syndrome (PCOS)‎ infertile females with diabetes mellitus prone to atherosclerosis

الملخص EN

positive correlation was found in GLP-1 levels with (LH) in G2 .

Results illustrated significant negative correlation was seen in levels of GLP-1 with LH/FSH ratio in G1,while there are a significant positive correlation in GLP-1 levels with LH/FSH ratio in G2 .

The conclusion could be drown from this study that GLP-1 has a correlation with LH , FSH which may be considered as a marker in PCOS patients with DM that prone to atherosclerosisThe study aimed to evaluate Glucagon-Like Peptide-1 levels in Polycystic ovary syndrome(PCOS) infertile female with Diabetes Mellitus (DM) and compare the results with control group , also , to find the correlation for GLP-1 with Luteinizing hormone(LH), Follicle stimulating hormone(FSH) and LH/FSH ratio that may be used in prediction atherosclerosis in these patients.

The study included nineteen women with age ranged(30-40) years and BMI ranged between (30-35) Kg/m2.

Subjects were divided into two groups: group(1) consist of (45)females as a healthy control and group(2) consist of (45) infertile females with PCOS and DM as complication .

Fasting serum glucose was determined by using commercial kits (Biolabo SA-France); LH , FSH , prolactin were determined by ELISA, fasting serum insulin was determined by using ELISA kit(DRG-Germany).Insulin-resistance(IR) calculated by (HOMA-IR) .

FSH , LH , LH/FSH ratio and prolactin levels for all studied groups were measured .

A highly significant elevation in prolactin, LH and LH/FSH ratio was found when G1 comparing with G2 .

While significant reduction seen in FSH levels in G2 comparing to G1 .

A high significant elevation in Fasting blood glucose , % HbA1C levels in patients group when comparing to healthy control .

Results revealed a highly significant elevation in insulin,HOMA-IR and glucagon, while there are a significant reduction in GLP-1levels.

There is significant positive correlation was found in GLP-1 levels with (FSH) in G1 ,while a significant negative correlation was observed in levels of GLP-1 and (FSH) inG2.

A significant negative correlation was found in GLP-1 levels and (LH) in G1 ,while a significant