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Novel biomarker in polycystic ovary syndrome (PCOS) infertile females with diabetes mellitus prone to atherosclerosis
Other Title(s)
مؤشرات حيوية جديدة لمتلازمة تكيس المبايض في النساء العقيمات المصابات بداء السكري و المعرضات لتصلب الشرايين
Joint Authors
al-Jawdah, Ban Mahmud Shakir
Shafiq, Nurhan Khalid
al-Tai, Raid Abd al-Munim Abd al-Hamid
Source
Iraqi National Journal of Chemistry
Issue
Vol. 16, Issue 1 (31 Mar. 2016), pp.1-12, 12 p.
Publisher
University of Babylon College of Sciences
Publication Date
2016-03-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract EN
positive correlation was found in GLP-1 levels with (LH) in G2 .
Results illustrated significant negative correlation was seen in levels of GLP-1 with LH/FSH ratio in G1,while there are a significant positive correlation in GLP-1 levels with LH/FSH ratio in G2 .
The conclusion could be drown from this study that GLP-1 has a correlation with LH , FSH which may be considered as a marker in PCOS patients with DM that prone to atherosclerosisThe study aimed to evaluate Glucagon-Like Peptide-1 levels in Polycystic ovary syndrome(PCOS) infertile female with Diabetes Mellitus (DM) and compare the results with control group , also , to find the correlation for GLP-1 with Luteinizing hormone(LH), Follicle stimulating hormone(FSH) and LH/FSH ratio that may be used in prediction atherosclerosis in these patients.
The study included nineteen women with age ranged(30-40) years and BMI ranged between (30-35) Kg/m2.
Subjects were divided into two groups: group(1) consist of (45)females as a healthy control and group(2) consist of (45) infertile females with PCOS and DM as complication .
Fasting serum glucose was determined by using commercial kits (Biolabo SA-France); LH , FSH , prolactin were determined by ELISA, fasting serum insulin was determined by using ELISA kit(DRG-Germany).Insulin-resistance(IR) calculated by (HOMA-IR) .
FSH , LH , LH/FSH ratio and prolactin levels for all studied groups were measured .
A highly significant elevation in prolactin, LH and LH/FSH ratio was found when G1 comparing with G2 .
While significant reduction seen in FSH levels in G2 comparing to G1 .
A high significant elevation in Fasting blood glucose , % HbA1C levels in patients group when comparing to healthy control .
Results revealed a highly significant elevation in insulin,HOMA-IR and glucagon, while there are a significant reduction in GLP-1levels.
There is significant positive correlation was found in GLP-1 levels with (FSH) in G1 ,while a significant negative correlation was observed in levels of GLP-1 and (FSH) inG2.
A significant negative correlation was found in GLP-1 levels and (LH) in G1 ,while a significant
American Psychological Association (APA)
al-Jawdah, Ban Mahmud Shakir& Shafiq, Nurhan Khalid& al-Tai, Raid Abd al-Munim Abd al-Hamid. 2016. Novel biomarker in polycystic ovary syndrome (PCOS) infertile females with diabetes mellitus prone to atherosclerosis. Iraqi National Journal of Chemistry،Vol. 16, no. 1, pp.1-12.
https://search.emarefa.net/detail/BIM-708355
Modern Language Association (MLA)
al-Jawdah, Ban Mahmud Shakir…[et al.]. Novel biomarker in polycystic ovary syndrome (PCOS) infertile females with diabetes mellitus prone to atherosclerosis. Iraqi National Journal of Chemistry Vol. 16, no. 1 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-708355
American Medical Association (AMA)
al-Jawdah, Ban Mahmud Shakir& Shafiq, Nurhan Khalid& al-Tai, Raid Abd al-Munim Abd al-Hamid. Novel biomarker in polycystic ovary syndrome (PCOS) infertile females with diabetes mellitus prone to atherosclerosis. Iraqi National Journal of Chemistry. 2016. Vol. 16, no. 1, pp.1-12.
https://search.emarefa.net/detail/BIM-708355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-11
Record ID
BIM-708355