Anti EGFR therapy in the treatment of non-metastatic head and neck squamous cell carcinoma : the current evidence
المؤلفون المشاركون
Julka, P. K.
Benson, Rony
Mallick, Supriya
Rath, G. K.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 28، العدد 3 (30 سبتمبر/أيلول 2016)، ص ص. 141-148، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2016-09-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Head and neck squamous cell carcinoma (HNSCC) accounts for a large oncologic burden in the developing countries.
In patients with locally advanced head and neck cancer multimodality treatment is warranted.
Radiation therapy with concurrent chemotherapy has long been considered the standard for patients with disease involving the oropharynx, larynx and hypopharynx.
However, addition of chemotherapy to radiotherapy increases treatment related toxicity by many folds and compliance rates decrease.
In this context a systemic therapy, which when used concurrent with radiation with favorable toxicity profile is of great importance for improving disease control in locally advanced HNSCC.
Anti-epithelial growth factor receptor targeted therapy emerged as a potential treatment option.
In recent years many trials were conducted to find the optimum treatment option with the combination of these targeted agents.
The initial trials showed excellent results with minimal morbidity and led to great enthusiasm across the globe to incorporate these regimens as a standard of care.
However, subsequently many trials failed to maintain such results and now there is little agreement to the initial results achieved with these drugs.
Based on the current evidence we cannot recommend the replacement of cisplatin with targeted therapy in concurrent setting.
It may be considered in patients with altered renal parameters, hypersensitivity or intolerance to cisplatin.
The addition of targeted therapy in addition to chemotherapy in the concurrent setting can’t also be recommended as the benefit is doubtful and is associated with a significant increase in toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Benson, Rony& Mallick, Supriya& Julka, P. K.& Rath, G. K.. 2016. Anti EGFR therapy in the treatment of non-metastatic head and neck squamous cell carcinoma : the current evidence. Journal of the Egyptian National Cancer Institute،Vol. 28, no. 3, pp.141-148.
https://search.emarefa.net/detail/BIM-708739
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Benson, Rony…[et al.]. Anti EGFR therapy in the treatment of non-metastatic head and neck squamous cell carcinoma : the current evidence. Journal of the Egyptian National Cancer Institute Vol. 28, no. 3 (Sep. 2016), pp.141-148.
https://search.emarefa.net/detail/BIM-708739
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Benson, Rony& Mallick, Supriya& Julka, P. K.& Rath, G. K.. Anti EGFR therapy in the treatment of non-metastatic head and neck squamous cell carcinoma : the current evidence. Journal of the Egyptian National Cancer Institute. 2016. Vol. 28, no. 3, pp.141-148.
https://search.emarefa.net/detail/BIM-708739
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 146-148
رقم السجل
BIM-708739
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر