In-vitro release of ketoprofen behavior loaded in polyvinyl alcohol acrylamide hydrogels prepared by gamma irradiation

الملخص EN

Hydrogels based on various ratios of polyvinyl alcohol (PVA) and acrylamide (AAm) were prepared by gamma radiation.

The formed hydrogels were characterized by spectroscopic analysis (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and swelling studied.

It was found that the thermal stability of the hydrogel decreases as the AAm content increases in the hydrogel.

The higher the AAm content in the hydrogel, the lower the values of Tm and ΔHm.

Ketoprofen was adopted as a model drug to study the adsorption and release behavior of (PVA/AAm) hydrogel.

The drug adsorption was decreased by increasing AAm ratio in the hydrogel.

From the in vitro drug release study in pH progressive media, the basic medium was showed comparatively the highest release and the (PVA/AAm) hydrogel of composition (70/30) was found to be the highest release one.

The mechanism of Ketoprofen release from the (PVA/AAm) matrix was found to be non-Fickian mechanism for all investigated hydrogels at pH 7.