In-vitro release of ketoprofen behavior loaded in polyvinyl alcohol acrylamide hydrogels prepared by gamma irradiation
Joint Authors
Kamal, H.
Mahmud, Ghadah A.
Hijazi, Dalia E.
Source
Arab Journal of Nuclear Sciences and Applications
Issue
Vol. 47, Issue 1 (28 Feb. 2014), pp.28-40, 13 p.
Publisher
The Egyptian Society of Nuclear Science and Applications
Publication Date
2014-02-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hydrogels based on various ratios of polyvinyl alcohol (PVA) and acrylamide (AAm) were prepared by gamma radiation.
The formed hydrogels were characterized by spectroscopic analysis (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and swelling studied.
It was found that the thermal stability of the hydrogel decreases as the AAm content increases in the hydrogel.
The higher the AAm content in the hydrogel, the lower the values of Tm and ΔHm.
Ketoprofen was adopted as a model drug to study the adsorption and release behavior of (PVA/AAm) hydrogel.
The drug adsorption was decreased by increasing AAm ratio in the hydrogel.
From the in vitro drug release study in pH progressive media, the basic medium was showed comparatively the highest release and the (PVA/AAm) hydrogel of composition (70/30) was found to be the highest release one.
The mechanism of Ketoprofen release from the (PVA/AAm) matrix was found to be non-Fickian mechanism for all investigated hydrogels at pH 7.
American Psychological Association (APA)
Mahmud, Ghadah A.& Hijazi, Dalia E.& Kamal, H.. 2014. In-vitro release of ketoprofen behavior loaded in polyvinyl alcohol acrylamide hydrogels prepared by gamma irradiation. Arab Journal of Nuclear Sciences and Applications،Vol. 47, no. 1, pp.28-40.
https://search.emarefa.net/detail/BIM-724201
Modern Language Association (MLA)
Mahmud, Ghadah A.…[et al.]. In-vitro release of ketoprofen behavior loaded in polyvinyl alcohol acrylamide hydrogels prepared by gamma irradiation. Arab Journal of Nuclear Sciences and Applications Vol. 47, no. 1 (Feb. 2014), pp.28-40.
https://search.emarefa.net/detail/BIM-724201
American Medical Association (AMA)
Mahmud, Ghadah A.& Hijazi, Dalia E.& Kamal, H.. In-vitro release of ketoprofen behavior loaded in polyvinyl alcohol acrylamide hydrogels prepared by gamma irradiation. Arab Journal of Nuclear Sciences and Applications. 2014. Vol. 47, no. 1, pp.28-40.
https://search.emarefa.net/detail/BIM-724201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 39-40
Record ID
BIM-724201
