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Association of insulin resistance with alanine aminotransferase activity in patients with nonalcoholic fatty liver disease
العناوين الأخرى
ارتباط مقاومة الأنسولين بنشاط الألأنين أمينوتر انسفيريز في مرضى الكبد الدهني الغير كحولي
المؤلفون المشاركون
Makkawi, Adil Hasan Muhammad
Ahmad, Hanan Mahmud
Muhammad, Wafa Salah
Yahya, Yahya Ahmad
المصدر
العدد
المجلد 39، العدد 2 (31 مايو/أيار 2015)، ص ص. 63-70، 8ص.
الناشر
تاريخ النشر
2015-05-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Background: Nonalcoholic fatty liver disease (NAFLD) is a term with a wide spectrum of disorders ranging from simple steatosis to progressive nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma.
Serum alanine aminotransferase (ALT) level is a well-recognized clinical marker of liver injury and may represent a consequence of the proinflammatory process accused in the pathogenesis of NAFLD.
Insulin resistance seems to predispose lipid accumulation within the liver and progress to fibrosis in NAFLD.
Aim of the study: to investigate the association cjf insulin resistance with ALT activity in NAFLD patients.
Patients and Methods: 50 patients with NAFLD, diagnosed by abdominal ultrasonography, were included in this study.
Full history, clinical evaluation, body mass index (BMI), waist circumference and laboratory tests including liver function tests, lipid profile, random blood glucose (RBG) and glycated Hemoglobin (HBAlc) were done.
Also, fasting blood glucose and fasting insulin levels were determined for calculation of Homeostasis Model Assessifnent-lnsulin Resistance (HOMA-1R).
Results : Patients were divided into two groups; group I included 28 patients with elevated serum ALT level and group II included 22 patients with normal serum ALT levil.
There was significant difference between the two groups as regard to prevalence of type 2 diabetes mellitus, elevated RBG level, HbAlc, HOMA-IR and waist circumference but no significant difference between the two groups regarding age, sex, BMI, lipid profile and incidence of hypertension and ischemic heart disease .
Conclusion :Our findings suggested that increased ALT activity was associated with insulin resistance in patients with NAFLD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Makkawi, Adil Hasan Muhammad& Ahmad, Hanan Mahmud& Muhammad, Wafa Salah& Yahya, Yahya Ahmad. 2015. Association of insulin resistance with alanine aminotransferase activity in patients with nonalcoholic fatty liver disease. Assiut Medical Journal،Vol. 39, no. 2, pp.63-70.
https://search.emarefa.net/detail/BIM-725957
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Makkawi, Adil Hasan Muhammad…[et al.]. Association of insulin resistance with alanine aminotransferase activity in patients with nonalcoholic fatty liver disease. Assiut Medical Journal Vol. 39, no. 2 (May. 2015), pp.63-70.
https://search.emarefa.net/detail/BIM-725957
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Makkawi, Adil Hasan Muhammad& Ahmad, Hanan Mahmud& Muhammad, Wafa Salah& Yahya, Yahya Ahmad. Association of insulin resistance with alanine aminotransferase activity in patients with nonalcoholic fatty liver disease. Assiut Medical Journal. 2015. Vol. 39, no. 2, pp.63-70.
https://search.emarefa.net/detail/BIM-725957
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 68-70
رقم السجل
BIM-725957
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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