Association of insulin resistance with alanine aminotransferase activity in patients with nonalcoholic fatty liver disease
Other Title(s)
ارتباط مقاومة الأنسولين بنشاط الألأنين أمينوتر انسفيريز في مرضى الكبد الدهني الغير كحولي
Joint Authors
Makkawi, Adil Hasan Muhammad
Ahmad, Hanan Mahmud
Muhammad, Wafa Salah
Yahya, Yahya Ahmad
Source
Issue
Vol. 39, Issue 2 (31 May. 2015), pp.63-70, 8 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2015-05-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Nonalcoholic fatty liver disease (NAFLD) is a term with a wide spectrum of disorders ranging from simple steatosis to progressive nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma.
Serum alanine aminotransferase (ALT) level is a well-recognized clinical marker of liver injury and may represent a consequence of the proinflammatory process accused in the pathogenesis of NAFLD.
Insulin resistance seems to predispose lipid accumulation within the liver and progress to fibrosis in NAFLD.
Aim of the study: to investigate the association cjf insulin resistance with ALT activity in NAFLD patients.
Patients and Methods: 50 patients with NAFLD, diagnosed by abdominal ultrasonography, were included in this study.
Full history, clinical evaluation, body mass index (BMI), waist circumference and laboratory tests including liver function tests, lipid profile, random blood glucose (RBG) and glycated Hemoglobin (HBAlc) were done.
Also, fasting blood glucose and fasting insulin levels were determined for calculation of Homeostasis Model Assessifnent-lnsulin Resistance (HOMA-1R).
Results : Patients were divided into two groups; group I included 28 patients with elevated serum ALT level and group II included 22 patients with normal serum ALT levil.
There was significant difference between the two groups as regard to prevalence of type 2 diabetes mellitus, elevated RBG level, HbAlc, HOMA-IR and waist circumference but no significant difference between the two groups regarding age, sex, BMI, lipid profile and incidence of hypertension and ischemic heart disease .
Conclusion :Our findings suggested that increased ALT activity was associated with insulin resistance in patients with NAFLD.
American Psychological Association (APA)
Makkawi, Adil Hasan Muhammad& Ahmad, Hanan Mahmud& Muhammad, Wafa Salah& Yahya, Yahya Ahmad. 2015. Association of insulin resistance with alanine aminotransferase activity in patients with nonalcoholic fatty liver disease. Assiut Medical Journal،Vol. 39, no. 2, pp.63-70.
https://search.emarefa.net/detail/BIM-725957
Modern Language Association (MLA)
Makkawi, Adil Hasan Muhammad…[et al.]. Association of insulin resistance with alanine aminotransferase activity in patients with nonalcoholic fatty liver disease. Assiut Medical Journal Vol. 39, no. 2 (May. 2015), pp.63-70.
https://search.emarefa.net/detail/BIM-725957
American Medical Association (AMA)
Makkawi, Adil Hasan Muhammad& Ahmad, Hanan Mahmud& Muhammad, Wafa Salah& Yahya, Yahya Ahmad. Association of insulin resistance with alanine aminotransferase activity in patients with nonalcoholic fatty liver disease. Assiut Medical Journal. 2015. Vol. 39, no. 2, pp.63-70.
https://search.emarefa.net/detail/BIM-725957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 68-70
Record ID
BIM-725957