Value of magnetic resonance spectroscopy in diagnosis of patients with focal brain lesion
العناوين الأخرى
دور التحليل الطيفي بالرنين المغناطيسي في تشخيص المرضى الذين يعانون من أفات الدماغ البؤرية
المؤلفون المشاركون
al-Jamal, Najih Fuli Kamil
Uthman, Mustafa Hashim
Yusuf, Ahmad Hamdi
Muhammad, Muhammad Mustafa Ahmad
Mahmud, Radwan Nubi
Darwish, Isam Sad
المصدر
العدد
المجلد 39، العدد 2 (31 مايو/أيار 2015)، ص ص. 215-224، 10ص.
الناشر
تاريخ النشر
2015-05-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Objective: To describe the spectrum of Magnetic Resonance spectroscopy in focal brain lesions and determine its diagnostic accuracy in comparison to conventional MRI using histopathology as gold standard in differentiating various types of focal brain space occupying lesions.
Patients and methods: 52 patients (21 males and 31 females) with single focal brain space occupying lesion diagnosed by post contrast CT or MRI are included in this study.
Complete clinical evaluation, MRIj and MRS examination were performed for all these patients before surgical biopsy and/or resection.
Correlation of all these findings was done with histopathology obtained in all these patients.
Results: The ijiost important markers in differentiating and grading various types of single focal brain space occupying lesion were choline level and choline/N-acetyl aspartate ratio.
There is statistically significant difference between mean of Cho/NAA in high grade glioma as it was 23.13 and low grade glioma where mean of choline/NAA was 6.21 (P value = 0.02).
Lipid and lactate peaks were more frequent in high grade tumors and lipid peak together with Choline/N-acetyl aspartate ratio could differentiate between metastasis and metastasis with delayed radiation necrosis.
Alanine peak appear to be pathognomonic for meningioma.
Perilesional MRS metabolites could detect actual histopathological (subclinical) extension and so differentiate between high grade and low grade tumors and between high grade tumors and metastasis.
Conclusion: MRI+MRS is more sensitive than MRI alone in diagnosis, differential diagnosis, and grading of focal brain space occupying lesion.
MR spectroscopy could differentiate various types of focal brain space occupying lesion with sensitivity of92 3% while sensitivity of MRI alone was 76.9%.
Abbreviations: CT: Computerized Tomography, cMRl: Conventional Magnetic Resonance Imaging, MRS: Magnetic Resonance Spectroscopy, Cho: Choline, NAA: N-acetyl Aspartate, Cr: Creatine, Lip: Lipids, Lac: Lactate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahmud, Radwan Nubi& Darwish, Isam Sad& al-Jamal, Najih Fuli Kamil& Uthman, Mustafa Hashim& Yusuf, Ahmad Hamdi& Muhammad, Muhammad Mustafa Ahmad. 2015. Value of magnetic resonance spectroscopy in diagnosis of patients with focal brain lesion. Assiut Medical Journal،Vol. 39, no. 2, pp.215-224.
https://search.emarefa.net/detail/BIM-725974
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahmud, Radwan Nubi…[et al.]. Value of magnetic resonance spectroscopy in diagnosis of patients with focal brain lesion. Assiut Medical Journal Vol. 39, no. 2 (May. 2015), pp.215-224.
https://search.emarefa.net/detail/BIM-725974
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahmud, Radwan Nubi& Darwish, Isam Sad& al-Jamal, Najih Fuli Kamil& Uthman, Mustafa Hashim& Yusuf, Ahmad Hamdi& Muhammad, Muhammad Mustafa Ahmad. Value of magnetic resonance spectroscopy in diagnosis of patients with focal brain lesion. Assiut Medical Journal. 2015. Vol. 39, no. 2, pp.215-224.
https://search.emarefa.net/detail/BIM-725974
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 221-223
رقم السجل
BIM-725974
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر