Value of magnetic resonance spectroscopy in diagnosis of patients with focal brain lesion
Other Title(s)
دور التحليل الطيفي بالرنين المغناطيسي في تشخيص المرضى الذين يعانون من أفات الدماغ البؤرية
Joint Authors
al-Jamal, Najih Fuli Kamil
Uthman, Mustafa Hashim
Yusuf, Ahmad Hamdi
Muhammad, Muhammad Mustafa Ahmad
Mahmud, Radwan Nubi
Darwish, Isam Sad
Source
Issue
Vol. 39, Issue 2 (31 May. 2015), pp.215-224, 10 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2015-05-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Objective: To describe the spectrum of Magnetic Resonance spectroscopy in focal brain lesions and determine its diagnostic accuracy in comparison to conventional MRI using histopathology as gold standard in differentiating various types of focal brain space occupying lesions.
Patients and methods: 52 patients (21 males and 31 females) with single focal brain space occupying lesion diagnosed by post contrast CT or MRI are included in this study.
Complete clinical evaluation, MRIj and MRS examination were performed for all these patients before surgical biopsy and/or resection.
Correlation of all these findings was done with histopathology obtained in all these patients.
Results: The ijiost important markers in differentiating and grading various types of single focal brain space occupying lesion were choline level and choline/N-acetyl aspartate ratio.
There is statistically significant difference between mean of Cho/NAA in high grade glioma as it was 23.13 and low grade glioma where mean of choline/NAA was 6.21 (P value = 0.02).
Lipid and lactate peaks were more frequent in high grade tumors and lipid peak together with Choline/N-acetyl aspartate ratio could differentiate between metastasis and metastasis with delayed radiation necrosis.
Alanine peak appear to be pathognomonic for meningioma.
Perilesional MRS metabolites could detect actual histopathological (subclinical) extension and so differentiate between high grade and low grade tumors and between high grade tumors and metastasis.
Conclusion: MRI+MRS is more sensitive than MRI alone in diagnosis, differential diagnosis, and grading of focal brain space occupying lesion.
MR spectroscopy could differentiate various types of focal brain space occupying lesion with sensitivity of92 3% while sensitivity of MRI alone was 76.9%.
Abbreviations: CT: Computerized Tomography, cMRl: Conventional Magnetic Resonance Imaging, MRS: Magnetic Resonance Spectroscopy, Cho: Choline, NAA: N-acetyl Aspartate, Cr: Creatine, Lip: Lipids, Lac: Lactate.
American Psychological Association (APA)
Mahmud, Radwan Nubi& Darwish, Isam Sad& al-Jamal, Najih Fuli Kamil& Uthman, Mustafa Hashim& Yusuf, Ahmad Hamdi& Muhammad, Muhammad Mustafa Ahmad. 2015. Value of magnetic resonance spectroscopy in diagnosis of patients with focal brain lesion. Assiut Medical Journal،Vol. 39, no. 2, pp.215-224.
https://search.emarefa.net/detail/BIM-725974
Modern Language Association (MLA)
Mahmud, Radwan Nubi…[et al.]. Value of magnetic resonance spectroscopy in diagnosis of patients with focal brain lesion. Assiut Medical Journal Vol. 39, no. 2 (May. 2015), pp.215-224.
https://search.emarefa.net/detail/BIM-725974
American Medical Association (AMA)
Mahmud, Radwan Nubi& Darwish, Isam Sad& al-Jamal, Najih Fuli Kamil& Uthman, Mustafa Hashim& Yusuf, Ahmad Hamdi& Muhammad, Muhammad Mustafa Ahmad. Value of magnetic resonance spectroscopy in diagnosis of patients with focal brain lesion. Assiut Medical Journal. 2015. Vol. 39, no. 2, pp.215-224.
https://search.emarefa.net/detail/BIM-725974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 221-223
Record ID
BIM-725974