Accelerated burn wound closure in mice with a new formula based on traditional medicine
المؤلفون المشاركون
Mehrabani, Mitra
Mehrabani, Mehrnaz
Seyyedkazemi, Sayyid Muhsin
Nimah Allahi, Muhammad Hadi
Jafari, Ilham
Mehdipour, Muhammad
Sheikhshoaee, Zahra
Mandegary, Ali
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 18، العدد 11 (30 نوفمبر/تشرين الثاني 2016)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2016-11-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Background : A combination of the oils of sesame, hemp, wild pistachio, and walnut has been used for treatment of skin disorders, including wound burns, in some parts of Kerman, Iran.
Evaluation of this remedy in the form of a pharmaceutical formulation in animal models can pave the way for its future application in wound burn healing in humans.
Objectives : This experimental study investigated the healing potential of a new formula (NF) based on folk medicine from Iran for the treatment of third degree burns in mice.
The formula was a combination of the oils of four plants: sesame (Sesamum indicum L.), wild pistachio (Pistacia atlantica Desf.), hemp (Cannabis sativa L.), and walnut (Juglans regia L.) Methods : Twenty-four mice were selected based on simple random sampling.
Twenty-five percent of the total body surface area was burned by exposure to boiling water, according to theWalker-Mason method.
NF and silver sulfadiazine (the positive control) were applied topically twice a day for 21 days.
The burned area in the negative control group was left untreated.
Epithelialization time and the percent of wound contraction were measured during the treatment period.
The process of wound repairing was evaluated using histological (H and E and trichrome staining) and immunohistological (anti-pancytokeratin) methods.
Results: Whencompared to the controls, NF significantly improvedwoundcontraction after day 10.
Epithelialization time in the NF group was significantly faster than in the other groups (20 vs.
25.5 days) (P < 0.001).
Histopathological and immunohistochemical findings confirmed the efficacy of the NF.
Conclusions : A new therapeutic remedy was introduced for the treatment of burn wounds.
Further clinical and molecular studies are suggested to determine the exact mechanism(s) involved in the burn wound healing effect of NF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mehrabani, Mehrnaz& Seyyedkazemi, Sayyid Muhsin& Nimah Allahi, Muhammad Hadi& Jafari, Ilham& Mehrabani, Mitra& Mehdipour, Muhammad…[et al.]. 2016. Accelerated burn wound closure in mice with a new formula based on traditional medicine. Iranian Red Crescent Medical Journal،Vol. 18, no. 11, pp.1-9.
https://search.emarefa.net/detail/BIM-728738
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mehrabani, Mehrnaz…[et al.]. Accelerated burn wound closure in mice with a new formula based on traditional medicine. Iranian Red Crescent Medical Journal Vol. 18, no. 11 (Nov. 2016), pp.1-9.
https://search.emarefa.net/detail/BIM-728738
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mehrabani, Mehrnaz& Seyyedkazemi, Sayyid Muhsin& Nimah Allahi, Muhammad Hadi& Jafari, Ilham& Mehrabani, Mitra& Mehdipour, Muhammad…[et al.]. Accelerated burn wound closure in mice with a new formula based on traditional medicine. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 11, pp.1-9.
https://search.emarefa.net/detail/BIM-728738
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-9
رقم السجل
BIM-728738
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر