Accelerated burn wound closure in mice with a new formula based on traditional medicine
Joint Authors
Mehrabani, Mitra
Mehrabani, Mehrnaz
Seyyedkazemi, Sayyid Muhsin
Nimah Allahi, Muhammad Hadi
Jafari, Ilham
Mehdipour, Muhammad
Sheikhshoaee, Zahra
Mandegary, Ali
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 11 (30 Nov. 2016), pp.1-9, 9 p.
Publisher
Publication Date
2016-11-30
Country of Publication
United Arab Emirates
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background : A combination of the oils of sesame, hemp, wild pistachio, and walnut has been used for treatment of skin disorders, including wound burns, in some parts of Kerman, Iran.
Evaluation of this remedy in the form of a pharmaceutical formulation in animal models can pave the way for its future application in wound burn healing in humans.
Objectives : This experimental study investigated the healing potential of a new formula (NF) based on folk medicine from Iran for the treatment of third degree burns in mice.
The formula was a combination of the oils of four plants: sesame (Sesamum indicum L.), wild pistachio (Pistacia atlantica Desf.), hemp (Cannabis sativa L.), and walnut (Juglans regia L.) Methods : Twenty-four mice were selected based on simple random sampling.
Twenty-five percent of the total body surface area was burned by exposure to boiling water, according to theWalker-Mason method.
NF and silver sulfadiazine (the positive control) were applied topically twice a day for 21 days.
The burned area in the negative control group was left untreated.
Epithelialization time and the percent of wound contraction were measured during the treatment period.
The process of wound repairing was evaluated using histological (H and E and trichrome staining) and immunohistological (anti-pancytokeratin) methods.
Results: Whencompared to the controls, NF significantly improvedwoundcontraction after day 10.
Epithelialization time in the NF group was significantly faster than in the other groups (20 vs.
25.5 days) (P < 0.001).
Histopathological and immunohistochemical findings confirmed the efficacy of the NF.
Conclusions : A new therapeutic remedy was introduced for the treatment of burn wounds.
Further clinical and molecular studies are suggested to determine the exact mechanism(s) involved in the burn wound healing effect of NF.
American Psychological Association (APA)
Mehrabani, Mehrnaz& Seyyedkazemi, Sayyid Muhsin& Nimah Allahi, Muhammad Hadi& Jafari, Ilham& Mehrabani, Mitra& Mehdipour, Muhammad…[et al.]. 2016. Accelerated burn wound closure in mice with a new formula based on traditional medicine. Iranian Red Crescent Medical Journal،Vol. 18, no. 11, pp.1-9.
https://search.emarefa.net/detail/BIM-728738
Modern Language Association (MLA)
Mehrabani, Mehrnaz…[et al.]. Accelerated burn wound closure in mice with a new formula based on traditional medicine. Iranian Red Crescent Medical Journal Vol. 18, no. 11 (Nov. 2016), pp.1-9.
https://search.emarefa.net/detail/BIM-728738
American Medical Association (AMA)
Mehrabani, Mehrnaz& Seyyedkazemi, Sayyid Muhsin& Nimah Allahi, Muhammad Hadi& Jafari, Ilham& Mehrabani, Mitra& Mehdipour, Muhammad…[et al.]. Accelerated burn wound closure in mice with a new formula based on traditional medicine. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 11, pp.1-9.
https://search.emarefa.net/detail/BIM-728738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-9
Record ID
BIM-728738