Prevalence of chlamydia pneumonia in patients with community acquired pneumonia (CAP)‎

العناوين الأخرى

انتشار بكتيريا الكلاميديا نوموني في المرضى الذين يعانون من الالتهاب الرئوي المكتسب

مقدم أطروحة جامعية

al-Hajaya, Tahani Salim

مشرف أطروحة جامعية

al-Zirini, Wail Ali Hasan
al-Yunus, Hisham Mahmud

أعضاء اللجنة

al-Tarawinah, Khalid
al-Mustafa, Ahmad Husayn Husayn
al-Nuaymat, Sulayman

الجامعة

جامعة مؤتة

الكلية

كلية العلوم

القسم الأكاديمي

قسم الأحياء

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2016

الملخص الإنجليزي

Chlamydia pneumoniae is a Gram-negative obligate intracellular bacterium, which is a major cause of acute respiratory tract diseases in human and has been responsible for both endemic and epidemic pneumonia..

The current study attempted to investigate the role of C.

pneumoniae in the CAP in Jordanian patients in Al-Karak Governorate.

A total of 133 nasopharyngeal swabs and sera (70 patients who have been diagnosed with CAP and admitted to hospital and 63 healthy control individuals) were included in this study.

The overall prevalence of C.

pneumoniae-specific IgG and IgM antibodies in sera collected from patients and controls were estimated by microimmunofluorescence method (MIF).The presence of C.

pneumoniae DNA was detected by standard PCR in nasopharyngeal sample.

An overall prevalence rate in anti-C.pneumoniae IgG was 1.45 time higher in patients diagnosed with CAP (44.3%) than that in healthy control (30.2%).

Moreover, the prevalence rate of anti-C.

pneumoniae IgM antibodies was significantly 8.6 time higher in CAP patients (27.1%) compared to control (3.2%) indicating a recent infection (p = 0.00009).

However, C.

pneumoniae DNA was detected in (40.0%) and (7.9%) of nasopharyngeal specimens from CAP patients and control individuals, respectively by using standard PCR.

Rate of C.

pneumoniae infection was age-dependent with highest prevalence rate among age group (≥ 65, 76.2%) in CAP patient and age group (50-64, 71.4%) in control individuals in term of IgG antibodies.

Meanwhile, highest prevalence rate was detected among age group (34- 49, 50%) in CAP patient and age group (50-64, 14.3%) in control individuals in term of IgM antibodies.

Acute infection (IgG ≥ 512) was detected 4.5 time more in CAP patients (7.14%) than in control cases (1.58%).

Furthermore, seronegative samples with positive PCR results in CAP patients indicate asymptomatic carrier patient individuals or persistence of C.

pneumoniae in the previous infection.

Herein, there was a correlation between MIF and PCR assays in detecting acute infections among CAP patients revealing that C.

pneumoniae as endemic etiological agents in CAP among Jordanian individuals in South Jordan, particularly in Al-Karak Governorate.

التخصصات الرئيسية

الأحياء

عدد الصفحات

75

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-731542