Prevalence of chlamydia pneumonia in patients with community acquired pneumonia (CAP)
Other Title(s)
انتشار بكتيريا الكلاميديا نوموني في المرضى الذين يعانون من الالتهاب الرئوي المكتسب
Dissertant
Thesis advisor
al-Zirini, Wail Ali Hasan
al-Yunus, Hisham Mahmud
Comitee Members
al-Tarawinah, Khalid
al-Mustafa, Ahmad Husayn Husayn
al-Nuaymat, Sulayman
University
Mutah University
Faculty
Faculty of Science
Department
Department of Biological Sciences
University Country
Jordan
Degree
Master
Degree Date
2016
English Abstract
Chlamydia pneumoniae is a Gram-negative obligate intracellular bacterium, which is a major cause of acute respiratory tract diseases in human and has been responsible for both endemic and epidemic pneumonia..
The current study attempted to investigate the role of C.
pneumoniae in the CAP in Jordanian patients in Al-Karak Governorate.
A total of 133 nasopharyngeal swabs and sera (70 patients who have been diagnosed with CAP and admitted to hospital and 63 healthy control individuals) were included in this study.
The overall prevalence of C.
pneumoniae-specific IgG and IgM antibodies in sera collected from patients and controls were estimated by microimmunofluorescence method (MIF).The presence of C.
pneumoniae DNA was detected by standard PCR in nasopharyngeal sample.
An overall prevalence rate in anti-C.pneumoniae IgG was 1.45 time higher in patients diagnosed with CAP (44.3%) than that in healthy control (30.2%).
Moreover, the prevalence rate of anti-C.
pneumoniae IgM antibodies was significantly 8.6 time higher in CAP patients (27.1%) compared to control (3.2%) indicating a recent infection (p = 0.00009).
However, C.
pneumoniae DNA was detected in (40.0%) and (7.9%) of nasopharyngeal specimens from CAP patients and control individuals, respectively by using standard PCR.
Rate of C.
pneumoniae infection was age-dependent with highest prevalence rate among age group (≥ 65, 76.2%) in CAP patient and age group (50-64, 71.4%) in control individuals in term of IgG antibodies.
Meanwhile, highest prevalence rate was detected among age group (34- 49, 50%) in CAP patient and age group (50-64, 14.3%) in control individuals in term of IgM antibodies.
Acute infection (IgG ≥ 512) was detected 4.5 time more in CAP patients (7.14%) than in control cases (1.58%).
Furthermore, seronegative samples with positive PCR results in CAP patients indicate asymptomatic carrier patient individuals or persistence of C.
pneumoniae in the previous infection.
Herein, there was a correlation between MIF and PCR assays in detecting acute infections among CAP patients revealing that C.
pneumoniae as endemic etiological agents in CAP among Jordanian individuals in South Jordan, particularly in Al-Karak Governorate.
Main Subjects
No. of Pages
75
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Theoretical background.
Chapter Two : Literature review.
Chapter Three : Design and methodology.
Chapter Four : Results, discussions, conclusions and recommendations.
References.
American Psychological Association (APA)
al-Hajaya, Tahani Salim. (2016). Prevalence of chlamydia pneumonia in patients with community acquired pneumonia (CAP). (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-731542
Modern Language Association (MLA)
al-Hajaya, Tahani Salim. Prevalence of chlamydia pneumonia in patients with community acquired pneumonia (CAP). (Master's theses Theses and Dissertations Master). Mutah University. (2016).
https://search.emarefa.net/detail/BIM-731542
American Medical Association (AMA)
al-Hajaya, Tahani Salim. (2016). Prevalence of chlamydia pneumonia in patients with community acquired pneumonia (CAP). (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-731542
Language
English
Data Type
Arab Theses
Record ID
BIM-731542
