Diagnostic value of anti-peptidylarginine deiminase type 4 (PADI-4)‎ and anti-cyclic citrullinated peptide antibodies (ACCP)‎ among Iraqi patients with rheumatoid arthritis

العناوين الأخرى

القيمة التشخيصية لمضادات الببتيدايل آرجنين -4 و لمضادات الببتيدية الحلقية الحاوية على السترولين بين المرضى العراقيين المصابين بالتهاب المفاصل الرثوي

مقدم أطروحة جامعية

Badran, Hisham Abd al-Jalil

مشرف أطروحة جامعية

Hassuni, Hasan J.

أعضاء اللجنة

Hamdan, Thamir Ahmad
Mahmud, Khalid Hasan
al-Hamdani, Adnan Hamad Ubayd
al-Abbasi, Ahmad M.

الجامعة

جامعة البصرة

الكلية

كلية الطب البيطري

القسم الأكاديمي

قسم الأحياء المجهرية

دولة الجامعة

العراق

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2014

الملخص الإنجليزي

Objective.

To examine the value of anti- peptidylarginine deiminase (anti-PADI-4) antibody and anti-cyclic citrullinated peptide (anti-CCP) antibody among Iraqi patients with RA and to determine whether the activity and severity in RA patients are associated with anti-PADI-4 and anti-CCP antibodies positivity .

Method.

In a case control study , we determined the seropositivity of these two serological markers anti-PADI-4 and anti-CCP antibodies in100 RA patients and 100 healthy control subjects .

Activity of disease were measured by disease activity score in 28 joints (DAS 28) and severity was assessed using Scott modification of the Larsen method.

Result.

Antibodies to PADI-4 were detected in 32 of 100 (32%)among RA patients and present 1 of 100 ( 1%) in controls (p < 0.001).

Anti-CCP was present in 74/100 (74%) of the RA patients and present in 2/100 (2%) in controls (p < 0.001) , sensitivity was highest for anti-CCP antibody (74%) followed by anti-PADI-4 antibody (32%).Specificity was highest for anti-PADI-4 antibody (99%) followed by anti-CCP antibody(98%).

A significant correlation with disease activity was observed in both markers , RA patients on remission had negative PADI-4 test (0/12) but patients with high disease activity showed higher percentage (86.4%) of PADI-4 seropositivity in comparison to anti-CCP where patients on remission had (8.3%) seropositivity and RA patients with high disease activity had (91%) anti-CCP seropositivity .

However , seropostivity to PADI-4 was significantly correlated with RA severity ( p < 0.001) as evaluated by scott method (59.3%) in grade 5 .

Similarly , there were a significant correlation between anti-CCP seropositivity and radiological finding but less than that associated with seropositivity to PADI-4 antibody (p < 0.05).

Conclusion.

With their excellent specificity , both anti-PADI-4 and anti-CCP antibodies can be useful in establishing the diagnosis of RA, and can be regarded as good predictors of disease activity and severity .

التخصصات الرئيسية

الأحياء

عدد الصفحات

151

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-744766