Developing a new micro emulsion using nonionic surfactants for transdermal and oral application of gentamicin in rats as animal model

العناوين الأخرى

تطوير مستحلب دقيق باستخدام تقنية العوامل الفعالة على السطح الغير متأنية من اجل التطبيق الجلدي و الفموي للجنتاميسين على الفئران كنموذج حيواني

مقدم أطروحة جامعية

al-Rabii, Ala Salih Mahdi

مشرف أطروحة جامعية

al-Krad, Jamal Yusuf

أعضاء اللجنة

al-Wakil, Jabbar
al-Khatib, Hatim

الجامعة

جامعة الإسراء

الكلية

كلية الصيدلة

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2017

الملخص الإنجليزي

Gentamycin (GS) is administered as intravenous or intramuscular solution because of its poor oral bioavailability.

However, the intravenous administration associated with pain and needs some skills.

In this study, five nonionic microemulsions (MEs) for oral and transdermal application were developed using nonionic surfactants.

The MEs were characterized for their droplets sizes, rheological properties.

Furthermore, the transdermal was evaluated by estimation the flux and permeability coefficient through rat’s skin using Franz diffusion cell.

The results show that the MEs complied with the colloidal properties.

The ME with highest flux of 1.892 mg/cm2*h of these formulations was chosen for further oral bioavailability in rats in comparison to an aqueous solution of GS.

The ME showed a percentage relative bioavailability of 239.7 % in comparison to an oral solution

التخصصات الرئيسية

علم الصيدلة

الموضوعات

عدد الصفحات

63

قائمة المحتويات

Table of contents.

Abstract.

Abstract in Arabic.

[Chapter One] : Introduction.

[Chapter Two] : Materials, instruments and methods

[Chapter Three] : Results.

[Chapter Four] : Discussion.

[Chapter Five] : Conclusion.

References.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

al-Rabii, Ala Salih Mahdi. (2017). Developing a new micro emulsion using nonionic surfactants for transdermal and oral application of gentamicin in rats as animal model. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-750369

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

al-Rabii, Ala Salih Mahdi. Developing a new micro emulsion using nonionic surfactants for transdermal and oral application of gentamicin in rats as animal model. (Master's theses Theses and Dissertations Master). Isra University. (2017).
https://search.emarefa.net/detail/BIM-750369

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

al-Rabii, Ala Salih Mahdi. (2017). Developing a new micro emulsion using nonionic surfactants for transdermal and oral application of gentamicin in rats as animal model. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-750369

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-750369