Developing a new micro emulsion using nonionic surfactants for transdermal and oral application of gentamicin in rats as animal model
Other Title(s)
تطوير مستحلب دقيق باستخدام تقنية العوامل الفعالة على السطح الغير متأنية من اجل التطبيق الجلدي و الفموي للجنتاميسين على الفئران كنموذج حيواني
Dissertant
Thesis advisor
Comitee Members
al-Wakil, Jabbar
al-Khatib, Hatim
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2017
English Abstract
Gentamycin (GS) is administered as intravenous or intramuscular solution because of its poor oral bioavailability.
However, the intravenous administration associated with pain and needs some skills.
In this study, five nonionic microemulsions (MEs) for oral and transdermal application were developed using nonionic surfactants.
The MEs were characterized for their droplets sizes, rheological properties.
Furthermore, the transdermal was evaluated by estimation the flux and permeability coefficient through rat’s skin using Franz diffusion cell.
The results show that the MEs complied with the colloidal properties.
The ME with highest flux of 1.892 mg/cm2*h of these formulations was chosen for further oral bioavailability in rats in comparison to an aqueous solution of GS.
The ME showed a percentage relative bioavailability of 239.7 % in comparison to an oral solution
Main Subjects
Topics
No. of Pages
63
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
[Chapter One] : Introduction.
[Chapter Two] : Materials, instruments and methods
[Chapter Three] : Results.
[Chapter Four] : Discussion.
[Chapter Five] : Conclusion.
References.
American Psychological Association (APA)
al-Rabii, Ala Salih Mahdi. (2017). Developing a new micro emulsion using nonionic surfactants for transdermal and oral application of gentamicin in rats as animal model. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-750369
Modern Language Association (MLA)
al-Rabii, Ala Salih Mahdi. Developing a new micro emulsion using nonionic surfactants for transdermal and oral application of gentamicin in rats as animal model. (Master's theses Theses and Dissertations Master). Isra University. (2017).
https://search.emarefa.net/detail/BIM-750369
American Medical Association (AMA)
al-Rabii, Ala Salih Mahdi. (2017). Developing a new micro emulsion using nonionic surfactants for transdermal and oral application of gentamicin in rats as animal model. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-750369
Language
English
Data Type
Arab Theses
Record ID
BIM-750369
