Association analysis of polymorphisms in EGFR, HER2, ESR1 and THRA genes with coronary artery diseases
المؤلفون المشاركون
Abd al-Hadi, Raniya
Bu Ayid, Nuha Abd al-Mawla
Abid, Layla
Rebai, Ahmad
Rabi, Maha
Kallel, Imen
Kharrat, Najla
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 18، العدد 3 (31 يوليو/تموز 2017)، ص ص. 241-248، 8ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2017-07-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background: Research in the genetic basis of coronary artery diseases (CAD) has identified some genes and pathways associated with diseases that would not be considered to underlie conventional risk factors.
Among these genes there are the EGFR (epidermal growth factor receptor) receptor family genes and the regulation factor genes (such as thyroid hormone receptor a (THRA) and estrogen receptor a (ESR1)).
Aim: In this study we investigated the relation between 4 polymorphisms within EGFR, HER2 (human epidermal growth factor receptor 2), ESR1 and THRA genes and CAD.
Subjects and methods: The association analysis was performed with 151 healthy individuals and 151 CAD patients documented by angiography.
Results: No significant difference was found in the allelic and genotypic frequency distribution of the four variants studied between the control and patient groups.
We have also investigated the relationship of these polymorphic sites with clinical and biochemical parameters such as smoking habit, diabetes mellitus, hypertension, dyslipidemia, CAD severity, glucose, triglyceride, total cholesterol and urea levels.
The EGFR and THRA variants were associated with glycemia and triglyceride levels, respectively.
Also a significant correlation was found between the ESR1 polymorphism and the levels of urea and triglyceride.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rabi, Maha& Kallel, Imen& Abd al-Hadi, Raniya& Kharrat, Najla& Bu Ayid, Nuha Abd al-Mawla& Abid, Layla…[et al.]. 2017. Association analysis of polymorphisms in EGFR, HER2, ESR1 and THRA genes with coronary artery diseases. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 3, pp.241-248.
https://search.emarefa.net/detail/BIM-760005
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rabi, Maha…[et al.]. Association analysis of polymorphisms in EGFR, HER2, ESR1 and THRA genes with coronary artery diseases. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 3 (Jul. 2017), pp.241-248.
https://search.emarefa.net/detail/BIM-760005
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rabi, Maha& Kallel, Imen& Abd al-Hadi, Raniya& Kharrat, Najla& Bu Ayid, Nuha Abd al-Mawla& Abid, Layla…[et al.]. Association analysis of polymorphisms in EGFR, HER2, ESR1 and THRA genes with coronary artery diseases. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 3, pp.241-248.
https://search.emarefa.net/detail/BIM-760005
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 247-248
رقم السجل
BIM-760005
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر