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Association analysis of polymorphisms in EGFR, HER2, ESR1 and THRA genes with coronary artery diseases
Joint Authors
Abd al-Hadi, Raniya
Bu Ayid, Nuha Abd al-Mawla
Abid, Layla
Rebai, Ahmad
Rabi, Maha
Kallel, Imen
Kharrat, Najla
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 18, Issue 3 (31 Jul. 2017), pp.241-248, 8 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2017-07-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background: Research in the genetic basis of coronary artery diseases (CAD) has identified some genes and pathways associated with diseases that would not be considered to underlie conventional risk factors.
Among these genes there are the EGFR (epidermal growth factor receptor) receptor family genes and the regulation factor genes (such as thyroid hormone receptor a (THRA) and estrogen receptor a (ESR1)).
Aim: In this study we investigated the relation between 4 polymorphisms within EGFR, HER2 (human epidermal growth factor receptor 2), ESR1 and THRA genes and CAD.
Subjects and methods: The association analysis was performed with 151 healthy individuals and 151 CAD patients documented by angiography.
Results: No significant difference was found in the allelic and genotypic frequency distribution of the four variants studied between the control and patient groups.
We have also investigated the relationship of these polymorphic sites with clinical and biochemical parameters such as smoking habit, diabetes mellitus, hypertension, dyslipidemia, CAD severity, glucose, triglyceride, total cholesterol and urea levels.
The EGFR and THRA variants were associated with glycemia and triglyceride levels, respectively.
Also a significant correlation was found between the ESR1 polymorphism and the levels of urea and triglyceride.
American Psychological Association (APA)
Rabi, Maha& Kallel, Imen& Abd al-Hadi, Raniya& Kharrat, Najla& Bu Ayid, Nuha Abd al-Mawla& Abid, Layla…[et al.]. 2017. Association analysis of polymorphisms in EGFR, HER2, ESR1 and THRA genes with coronary artery diseases. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 3, pp.241-248.
https://search.emarefa.net/detail/BIM-760005
Modern Language Association (MLA)
Rabi, Maha…[et al.]. Association analysis of polymorphisms in EGFR, HER2, ESR1 and THRA genes with coronary artery diseases. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 3 (Jul. 2017), pp.241-248.
https://search.emarefa.net/detail/BIM-760005
American Medical Association (AMA)
Rabi, Maha& Kallel, Imen& Abd al-Hadi, Raniya& Kharrat, Najla& Bu Ayid, Nuha Abd al-Mawla& Abid, Layla…[et al.]. Association analysis of polymorphisms in EGFR, HER2, ESR1 and THRA genes with coronary artery diseases. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 3, pp.241-248.
https://search.emarefa.net/detail/BIM-760005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 247-248
Record ID
BIM-760005