Metabolic derangements in IUGR neonates detected at birth using UPLC-MS
المؤلفون المشاركون
al-Farghali, O. G.
al-Abd, H. S. A.
al-Dasuqi, E. D.
Abd al-Wahid, M. A.
Hasan, S. M.
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 18، العدد 3 (31 يوليو/تموز 2017)، ص ص. 281-287، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2017-07-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background: Intrauterine growth restriction (IUGR) is associated with short- and long-term metabolic consequences which are possibly dictated by in utero programming together with environmental and dietetic manipulation after birth.
Early detection of metabolic derangements in these babies through metabolomics approach will help recognition of cases in need for further follow-up and can help future development of therapeutic and preventive strategies for the late consequences.
Objective: To compare amino acids and acyl carnitine levels in neonates with IUGR to normal birth weight controls; as a part of metabolic profiling.
Methods: Cord blood samples were collected at birth from 40 small-for-gestational-age (SGA) neonates and 20 normal birth weight gestational age-matched neonates, for quantification of amino acids and acylcarnitines using Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS).
Results: Significantly elevated acylcarnitine levels especially C18-OH and C16-OH were found in IUGR neonates vs.
controls (p < 0.001).
Specific amino acids that were significantly elevated in IUGR neonates included Histidine, Methionine, Arginine, Aspartic, Valine, Alanine, Leucine, Isoleucine, Glutamic acid, Tyrosine, Ornithine, Phenylalanine, and lastly citrulline.
These derangements were recognized to be similar to those found in different disorders.
Conclusion: We conclude that IUGR neonates have unique metabolic derangements detectable by UPLCMS at birth with similarities to derangements found in certain disorders.
These babies should be closely followed up for early detection of the metabolic consequences of IUGR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Wahid, M. A.& al-Farghali, O. G.& al-Abd, H. S. A.& al-Dasuqi, E. D.& Hasan, S. M.. 2017. Metabolic derangements in IUGR neonates detected at birth using UPLC-MS. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 3, pp.281-287.
https://search.emarefa.net/detail/BIM-760017
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Wahid, M. A.…[et al.]. Metabolic derangements in IUGR neonates detected at birth using UPLC-MS. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 3 (Jul. 2017), pp.281-287.
https://search.emarefa.net/detail/BIM-760017
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Wahid, M. A.& al-Farghali, O. G.& al-Abd, H. S. A.& al-Dasuqi, E. D.& Hasan, S. M.. Metabolic derangements in IUGR neonates detected at birth using UPLC-MS. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 3, pp.281-287.
https://search.emarefa.net/detail/BIM-760017
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 286-287
رقم السجل
BIM-760017
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر