Metabolic derangements in IUGR neonates detected at birth using UPLC-MS
Joint Authors
al-Farghali, O. G.
al-Abd, H. S. A.
al-Dasuqi, E. D.
Abd al-Wahid, M. A.
Hasan, S. M.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 18, Issue 3 (31 Jul. 2017), pp.281-287, 7 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2017-07-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background: Intrauterine growth restriction (IUGR) is associated with short- and long-term metabolic consequences which are possibly dictated by in utero programming together with environmental and dietetic manipulation after birth.
Early detection of metabolic derangements in these babies through metabolomics approach will help recognition of cases in need for further follow-up and can help future development of therapeutic and preventive strategies for the late consequences.
Objective: To compare amino acids and acyl carnitine levels in neonates with IUGR to normal birth weight controls; as a part of metabolic profiling.
Methods: Cord blood samples were collected at birth from 40 small-for-gestational-age (SGA) neonates and 20 normal birth weight gestational age-matched neonates, for quantification of amino acids and acylcarnitines using Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS).
Results: Significantly elevated acylcarnitine levels especially C18-OH and C16-OH were found in IUGR neonates vs.
controls (p < 0.001).
Specific amino acids that were significantly elevated in IUGR neonates included Histidine, Methionine, Arginine, Aspartic, Valine, Alanine, Leucine, Isoleucine, Glutamic acid, Tyrosine, Ornithine, Phenylalanine, and lastly citrulline.
These derangements were recognized to be similar to those found in different disorders.
Conclusion: We conclude that IUGR neonates have unique metabolic derangements detectable by UPLCMS at birth with similarities to derangements found in certain disorders.
These babies should be closely followed up for early detection of the metabolic consequences of IUGR.
American Psychological Association (APA)
Abd al-Wahid, M. A.& al-Farghali, O. G.& al-Abd, H. S. A.& al-Dasuqi, E. D.& Hasan, S. M.. 2017. Metabolic derangements in IUGR neonates detected at birth using UPLC-MS. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 3, pp.281-287.
https://search.emarefa.net/detail/BIM-760017
Modern Language Association (MLA)
Abd al-Wahid, M. A.…[et al.]. Metabolic derangements in IUGR neonates detected at birth using UPLC-MS. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 3 (Jul. 2017), pp.281-287.
https://search.emarefa.net/detail/BIM-760017
American Medical Association (AMA)
Abd al-Wahid, M. A.& al-Farghali, O. G.& al-Abd, H. S. A.& al-Dasuqi, E. D.& Hasan, S. M.. Metabolic derangements in IUGR neonates detected at birth using UPLC-MS. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 3, pp.281-287.
https://search.emarefa.net/detail/BIM-760017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 286-287
Record ID
BIM-760017