The effect of ascorbic acid on Bitis arietans venom induced toxicity in rats
المؤلفون المشاركون
Uthman, Nasir al-Din M. A.
al-Asmari, Sarah A.
Mundhiri, Raja Muhammad Abbas
al-Asmari, Abd al-Rahman K.
المصدر
Arab Journal of Basic and Applied Sciences
العدد
المجلد 24، العدد 0 (31 أكتوبر/تشرين الأول 2017)، ص ص. 89-94، 6ص.
الناشر
تاريخ النشر
2017-10-31
دولة النشر
البحرين
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Ascorbic acid (AsAc) was tested to evaluate its ability to reverse the oxidative stress induced by envenoming.
Test groups of rats were envenomed with sub-lethal doses (4.0 mg/kg s.
c.) of Bitis arietans venom (BaV) whilst, single doses (500 mg/kg, orally) of AsAc were preadministered in half of them.
Blood samples were collected within three periods and levels of lipid peroxidation (LPO) and total-SH increased significantly, whilst, the ‘Venom + AsAc’ groups were significantly less than both, the respective ‘Venom’ groups and controls, at different periods.
The antioxidant, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzyme level changes were trivial at the three periods, whilst, there were no changes in the ‘Venom + AsAc’ groups, compared with controls, except SOD which, became significant after 24 h.
SCr and BUN levels were significantly higher than the controls within the three periods with variable degrees, whilst, the ‘Venom + AsAc’ group level changes were insignificant compared with controls and their respective ‘Venom’ groups at all periods.
Blood urea Nitrogen (BUN), became significantly lower after 24 h.
After 6 and 24 h AST levels were significantly higher than controls, whilst, ALT was not.
Level changes of both AST and ALT ‘Venom + AsAc’ groups were insignificant, compared with controls at all periods.
It is concluded that oxidative stress due to envenoming by BaV induced variable levels of significant changes in levels of nephrotoxic, hepatotoxic markers and antioxidant enzyme parameters.
Administration of AsAc relatively adjusted these changes with different degrees, at variable periods of time that demands further deeper research in beneficiary mechanisms of antioxidants.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Asmari, Abd al-Rahman K.& Uthman, Nasir al-Din M. A.& Mundhiri, Raja Muhammad Abbas& al-Asmari, Sarah A.. 2017. The effect of ascorbic acid on Bitis arietans venom induced toxicity in rats. Arab Journal of Basic and Applied Sciences،Vol. 24, no. 0, pp.89-94.
https://search.emarefa.net/detail/BIM-760584
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Asmari, Abd al-Rahman K.…[et al.]. The effect of ascorbic acid on Bitis arietans venom induced toxicity in rats. Arab Journal of Basic and Applied Sciences Vol. 24 (Oct. 2017), pp.89-94.
https://search.emarefa.net/detail/BIM-760584
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Asmari, Abd al-Rahman K.& Uthman, Nasir al-Din M. A.& Mundhiri, Raja Muhammad Abbas& al-Asmari, Sarah A.. The effect of ascorbic acid on Bitis arietans venom induced toxicity in rats. Arab Journal of Basic and Applied Sciences. 2017. Vol. 24, no. 0, pp.89-94.
https://search.emarefa.net/detail/BIM-760584
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 93-94
رقم السجل
BIM-760584
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر