The effect of ascorbic acid on Bitis arietans venom induced toxicity in rats
Joint Authors
Uthman, Nasir al-Din M. A.
al-Asmari, Sarah A.
Mundhiri, Raja Muhammad Abbas
al-Asmari, Abd al-Rahman K.
Source
Arab Journal of Basic and Applied Sciences
Issue
Vol. 24, Issue 0 (31 Oct. 2017), pp.89-94, 6 p.
Publisher
University of Bahrain College of Science
Publication Date
2017-10-31
Country of Publication
Bahrain
No. of Pages
6
Main Subjects
Topics
Abstract EN
Ascorbic acid (AsAc) was tested to evaluate its ability to reverse the oxidative stress induced by envenoming.
Test groups of rats were envenomed with sub-lethal doses (4.0 mg/kg s.
c.) of Bitis arietans venom (BaV) whilst, single doses (500 mg/kg, orally) of AsAc were preadministered in half of them.
Blood samples were collected within three periods and levels of lipid peroxidation (LPO) and total-SH increased significantly, whilst, the ‘Venom + AsAc’ groups were significantly less than both, the respective ‘Venom’ groups and controls, at different periods.
The antioxidant, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzyme level changes were trivial at the three periods, whilst, there were no changes in the ‘Venom + AsAc’ groups, compared with controls, except SOD which, became significant after 24 h.
SCr and BUN levels were significantly higher than the controls within the three periods with variable degrees, whilst, the ‘Venom + AsAc’ group level changes were insignificant compared with controls and their respective ‘Venom’ groups at all periods.
Blood urea Nitrogen (BUN), became significantly lower after 24 h.
After 6 and 24 h AST levels were significantly higher than controls, whilst, ALT was not.
Level changes of both AST and ALT ‘Venom + AsAc’ groups were insignificant, compared with controls at all periods.
It is concluded that oxidative stress due to envenoming by BaV induced variable levels of significant changes in levels of nephrotoxic, hepatotoxic markers and antioxidant enzyme parameters.
Administration of AsAc relatively adjusted these changes with different degrees, at variable periods of time that demands further deeper research in beneficiary mechanisms of antioxidants.
American Psychological Association (APA)
al-Asmari, Abd al-Rahman K.& Uthman, Nasir al-Din M. A.& Mundhiri, Raja Muhammad Abbas& al-Asmari, Sarah A.. 2017. The effect of ascorbic acid on Bitis arietans venom induced toxicity in rats. Arab Journal of Basic and Applied Sciences،Vol. 24, no. 0, pp.89-94.
https://search.emarefa.net/detail/BIM-760584
Modern Language Association (MLA)
al-Asmari, Abd al-Rahman K.…[et al.]. The effect of ascorbic acid on Bitis arietans venom induced toxicity in rats. Arab Journal of Basic and Applied Sciences Vol. 24 (Oct. 2017), pp.89-94.
https://search.emarefa.net/detail/BIM-760584
American Medical Association (AMA)
al-Asmari, Abd al-Rahman K.& Uthman, Nasir al-Din M. A.& Mundhiri, Raja Muhammad Abbas& al-Asmari, Sarah A.. The effect of ascorbic acid on Bitis arietans venom induced toxicity in rats. Arab Journal of Basic and Applied Sciences. 2017. Vol. 24, no. 0, pp.89-94.
https://search.emarefa.net/detail/BIM-760584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 93-94
Record ID
BIM-760584