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Micro RNA-146a expression as a potential biomarker for rheumatoid arthritis in Egypt
المؤلفون المشاركون
Hamdi, Maha Salah Al-Din
Murshidi, Nashwh Ali
al-Sayyid, Hibah Muhammad Abd al-Qadir
Khatir, Wala Shawqi
Ibrahim, Ayman Asaad
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 18، العدد 2 (30 إبريل/نيسان 2017)، ص ص. 173-179، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2017-04-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRNAs) are small non-coding RNAs, whose role in regulating diverse immune functions, suggests they might play a role as biomarkers for immune mediated disorders.
Studies showed that miRNA-146a (miR-146a) expression is increased by proinflammatory cytokines and is an important modulator of differentiation and function of cells of innate and adaptive immunity.
Aim of the work: The current study aimed to evaluate the expression of miR-146a as a potential biomarker for diagnosis of rheumatoid arthritis (RA) and to explore its association with disease activity.
Subjects and methods: The study enrolled 50 Egyptian subjects divided into a patient group, which comprised 25 RA patients, and a control group which comprised 25 healthy individuals.
The disease activity for the patients’ group was determined by simplified disease activity index.
Relative quantification of miR-146a expression in whole blood was determined using reverse transcriptase quantitative real time polymerase chain reaction.
Results: There were highly significant statistical differences between patients and healthy controls as regards miR-146a relative expression, erythrocyte sedimentation rate (ESR) and anticyclic citrullinated peptide (anti-CCP) (p< 0.001).
Highly significant statistical differences (p< 0.001) were also found between different patients’ subgroups as regards miR-146a relative expression and ESR.
miR-146a levels correlated positively with those of ESR, C-reactive protein and anti-CCP (p< 0.001).
miR-146a illustrated best performance in diagnosing RA, showing the highest sensitivity and specificity (96% and 100%, respectively) (AUC: 0.992 at a cut off value of P2.16) compared to anti-CCP (sensitivity: 68%, specificity: 100% and AUC: 0.87 at a cut off value of P22 U/ml) and RF (sensitivity: 56%, specificity: 80% and AUC: 0.992 at a cut off value of P13 U/ml).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sayyid, Hibah Muhammad Abd al-Qadir& Khatir, Wala Shawqi& Ibrahim, Ayman Asaad& Hamdi, Maha Salah Al-Din& Murshidi, Nashwh Ali. 2017. Micro RNA-146a expression as a potential biomarker for rheumatoid arthritis in Egypt. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 2, pp.173-179.
https://search.emarefa.net/detail/BIM-760949
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sayyid, Hibah Muhammad Abd al-Qadir…[et al.]. Micro RNA-146a expression as a potential biomarker for rheumatoid arthritis in Egypt. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 2 (Apr. 2017), pp.173-179.
https://search.emarefa.net/detail/BIM-760949
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sayyid, Hibah Muhammad Abd al-Qadir& Khatir, Wala Shawqi& Ibrahim, Ayman Asaad& Hamdi, Maha Salah Al-Din& Murshidi, Nashwh Ali. Micro RNA-146a expression as a potential biomarker for rheumatoid arthritis in Egypt. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 2, pp.173-179.
https://search.emarefa.net/detail/BIM-760949
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 178
رقم السجل
BIM-760949
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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