Role of novel cardiac bio markers in prediction, diagnosis, and severity assessmenl of atherosclerotic coronary artjary disease
العناوين الأخرى
دور دلالات القلب البيولوجية الحديثة في التنبؤ و تشخيص و تحديد شدة تصلب شرايين القلب التاجية
المؤلفون المشاركون
Muhammad, Hamdi Shams al-Din
al-Amiri, Nadir Abd al-raqib Murshid
Abd al-Qadir, Samir Sayyid
Abd al-Basit, Hisham Abd al-Rahim
Kishk, Yahya Taha
المصدر
العدد
المجلد 38، العدد 2 (31 مايو/أيار 2014)، ص ص. 185-198، 14ص.
الناشر
تاريخ النشر
2014-05-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Allwruxclerolic cardiovascular disease is a major health problem around the world.
Insulin resistance assessed by homeostatic model assessment of insulin resistance (HOMA-IR), triglyceride/ IIDL, serum high sensitive C-reactive protein (hs-CRP), and HbAlc are probably associated with alherosclerosis.
The aim of this study was to find if there was an association between HOMA-IR, triglyceride/ HDL ratio and their product as well as hs-CRP and HbAlc with the presence and the severity of coronary artery disease and to find the best cut off' value for clinical practice.
Methods: The study involved 170 consecutive patienis with suspected or known CAD referred for coronary angiography divided into two groups; CAD ip-oup (Group I) and non CAD group (Group II) based on coronary angiography.
The blood samples including HbAlc, hs-C-reactive protein, fasting bjood glucose, creatinine, urea, insulin and lipid spectrum were obtained after overnight fasting.
Results: Patients with CAD had higher HOMA-IR than those no CAD (4.47 ± 4.26 vs.
2.49 ± 1.99, P=0.002).
Stepwise multiple logistic regression analysis demonstrated that HOMA-IR > 2.66 was independently associated with CAD (odds ratio: 3.057 ; 93% confidence interval: 1.211-7.717; P=0.018) after adjustment for age, male sex, diabetes and waist circumference.
HOMA-IR correlates positively with BMl (P 0008 & r-^0.227), waist circumference (P=^0.002 & r=0.267 ) and HbAlc (P^O.015 & r 0.213 ).
Also IlOMA-IR^TG/HDL was higher in patients with CAD compared to those no CAD (IH.35 1 22.72 vi, 9.50 i 10.50, P-0.018).
However there were insignificant differences in levels of triglyceride/IIDL, HbAlc, and hs-CRP among both groups (P= 0.124, 0.523, 0.250 & 0.764 respectivelyj.
IlOMI-IR was significantly higher in patients with DVD (Double-vessel.
Disease) and MVD (Multi-vessel Disease) compared to patients with no CAD (P-0.002 & 0.000^respectively).
Moreover HOMA-IR was significantly higher in patients with DVD and MVD compared to patients with SVD (Single-vessel Disease) (P^O.035, 0.001 respectively).
HOMA-IRxTG/HDL was significantly increased in DVD and MVD patients (P=0.012 & 0.001 respectively) compared to patients with no CAD and also when compared to patients with SVD (P=0.005 & 0.000 respectively).
Conclusion: HOMA-IR is considered as a marker for prediction of CAD and se'verity assessment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Amiri, Nadir Abd al-raqib Murshid& Abd al-Qadir, Samir Sayyid& Kishk, Yahya Taha& Abd al-Basit, Hisham Abd al-Rahim& Muhammad, Hamdi Shams al-Din. 2014. Role of novel cardiac bio markers in prediction, diagnosis, and severity assessmenl of atherosclerotic coronary artjary disease. Assiut Medical Journal،Vol. 38, no. 2, pp.185-198.
https://search.emarefa.net/detail/BIM-760987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Qadir, Samir Sayyid…[et al.]. Role of novel cardiac bio markers in prediction, diagnosis, and severity assessmenl of atherosclerotic coronary artjary disease. Assiut Medical Journal Vol. 38, no. 2 (May. 2014), pp.185-198.
https://search.emarefa.net/detail/BIM-760987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Amiri, Nadir Abd al-raqib Murshid& Abd al-Qadir, Samir Sayyid& Kishk, Yahya Taha& Abd al-Basit, Hisham Abd al-Rahim& Muhammad, Hamdi Shams al-Din. Role of novel cardiac bio markers in prediction, diagnosis, and severity assessmenl of atherosclerotic coronary artjary disease. Assiut Medical Journal. 2014. Vol. 38, no. 2, pp.185-198.
https://search.emarefa.net/detail/BIM-760987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 194-198
رقم السجل
BIM-760987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر