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Role of novel cardiac bio markers in prediction, diagnosis, and severity assessmenl of atherosclerotic coronary artjary disease
Other Title(s)
دور دلالات القلب البيولوجية الحديثة في التنبؤ و تشخيص و تحديد شدة تصلب شرايين القلب التاجية
Joint Authors
Muhammad, Hamdi Shams al-Din
al-Amiri, Nadir Abd al-raqib Murshid
Abd al-Qadir, Samir Sayyid
Abd al-Basit, Hisham Abd al-Rahim
Kishk, Yahya Taha
Source
Issue
Vol. 38, Issue 2 (31 May. 2014), pp.185-198, 14 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2014-05-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Allwruxclerolic cardiovascular disease is a major health problem around the world.
Insulin resistance assessed by homeostatic model assessment of insulin resistance (HOMA-IR), triglyceride/ IIDL, serum high sensitive C-reactive protein (hs-CRP), and HbAlc are probably associated with alherosclerosis.
The aim of this study was to find if there was an association between HOMA-IR, triglyceride/ HDL ratio and their product as well as hs-CRP and HbAlc with the presence and the severity of coronary artery disease and to find the best cut off' value for clinical practice.
Methods: The study involved 170 consecutive patienis with suspected or known CAD referred for coronary angiography divided into two groups; CAD ip-oup (Group I) and non CAD group (Group II) based on coronary angiography.
The blood samples including HbAlc, hs-C-reactive protein, fasting bjood glucose, creatinine, urea, insulin and lipid spectrum were obtained after overnight fasting.
Results: Patients with CAD had higher HOMA-IR than those no CAD (4.47 ± 4.26 vs.
2.49 ± 1.99, P=0.002).
Stepwise multiple logistic regression analysis demonstrated that HOMA-IR > 2.66 was independently associated with CAD (odds ratio: 3.057 ; 93% confidence interval: 1.211-7.717; P=0.018) after adjustment for age, male sex, diabetes and waist circumference.
HOMA-IR correlates positively with BMl (P 0008 & r-^0.227), waist circumference (P=^0.002 & r=0.267 ) and HbAlc (P^O.015 & r 0.213 ).
Also IlOMA-IR^TG/HDL was higher in patients with CAD compared to those no CAD (IH.35 1 22.72 vi, 9.50 i 10.50, P-0.018).
However there were insignificant differences in levels of triglyceride/IIDL, HbAlc, and hs-CRP among both groups (P= 0.124, 0.523, 0.250 & 0.764 respectivelyj.
IlOMI-IR was significantly higher in patients with DVD (Double-vessel.
Disease) and MVD (Multi-vessel Disease) compared to patients with no CAD (P-0.002 & 0.000^respectively).
Moreover HOMA-IR was significantly higher in patients with DVD and MVD compared to patients with SVD (Single-vessel Disease) (P^O.035, 0.001 respectively).
HOMA-IRxTG/HDL was significantly increased in DVD and MVD patients (P=0.012 & 0.001 respectively) compared to patients with no CAD and also when compared to patients with SVD (P=0.005 & 0.000 respectively).
Conclusion: HOMA-IR is considered as a marker for prediction of CAD and se'verity assessment.
American Psychological Association (APA)
al-Amiri, Nadir Abd al-raqib Murshid& Abd al-Qadir, Samir Sayyid& Kishk, Yahya Taha& Abd al-Basit, Hisham Abd al-Rahim& Muhammad, Hamdi Shams al-Din. 2014. Role of novel cardiac bio markers in prediction, diagnosis, and severity assessmenl of atherosclerotic coronary artjary disease. Assiut Medical Journal،Vol. 38, no. 2, pp.185-198.
https://search.emarefa.net/detail/BIM-760987
Modern Language Association (MLA)
al-Amiri, Nadir Abd al-raqib Murshid…[et al.]. Role of novel cardiac bio markers in prediction, diagnosis, and severity assessmenl of atherosclerotic coronary artjary disease. Assiut Medical Journal Vol. 38, no. 2 (May. 2014), pp.185-198.
https://search.emarefa.net/detail/BIM-760987
American Medical Association (AMA)
al-Amiri, Nadir Abd al-raqib Murshid& Abd al-Qadir, Samir Sayyid& Kishk, Yahya Taha& Abd al-Basit, Hisham Abd al-Rahim& Muhammad, Hamdi Shams al-Din. Role of novel cardiac bio markers in prediction, diagnosis, and severity assessmenl of atherosclerotic coronary artjary disease. Assiut Medical Journal. 2014. Vol. 38, no. 2, pp.185-198.
https://search.emarefa.net/detail/BIM-760987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 194-198
Record ID
BIM-760987