Effect of garlic and atorvastatin on leptin and lipid profile in triton x-100 induced hyperlipidemia in rats
المؤلفون المشاركون
Abd al-Hamid, Hatim S.
Sadiq, Qadri M.
Abd al-Aziz, Ahmad Z.
Taha, Nabil
المصدر
Kafr El-Sheikh Veterinary Medical Journal
العدد
المجلد 12، العدد 2 (31 ديسمبر/كانون الأول 2014)، ص ص. 109-127، 19ص.
الناشر
جامعة كفر الشيخ كلية الطب البيطري
تاريخ النشر
2014-12-31
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الموضوعات
الملخص EN
Hyperlipidemia is widely known to be the major risk factor for the development of cardiovascular diseases.
This study was conducted to determine the effect of Garlic on Leptin hormone and Lipid Profile in Triton x-100 induced hyperlipidemic rats compared with standard hypolipidemic Atorvasta in.
A total number of 60 albino rats were allocated into six equal groups, 10 rats each.
The first group was kept on Standard pellet diet (served as normal control), the second group was kept on 1% garlic added to standard pellet diet, the third group was administered with standard Atorvastatin 10 mg/kg p.o.
daily (served as standard), the forth group was given a single dose of triton at a dose 100 mg/kg and repeated every two weeks, i.p.
(served as Triton control), fifth and sixth groups were given a single dose of triton at a dose 100 mg/kg and repeated every two weeks, i.p.
and the fifth group was given arlic 1% added to standard pellet diet while sixth group was administered with standard Atorvastatin 10 mg/kg p.o.
(served as treated groups), after inducing hyperlipidemia (for 6 weeks).
Results showed that, garlic significantly decreased cholesterol, LDL-C, VLDL-C and TG and significantly increased HDL compared with triton x-100 -treated group.
On the other hand, there were a non significant differences in total lipid, phospholipids and leptin levels compared with triton x-100 -treated group.
We concluded that, Garlic has definite antihyperlipidemic activity in Triton X-100 induced hyperlipidemia model which is equipotent activity when compared with Atorvastatin.
This might returned in addition to its own hypolipidemc activity to increased leptin sensitivity in hypothalamus.
Further studies on Garlic needed to identify the possible mechanism of action on leptin hormone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Taha, Nabil& Abd al-Hamid, Hatim S.& Sadiq, Qadri M.& Abd al-Aziz, Ahmad Z.. 2014. Effect of garlic and atorvastatin on leptin and lipid profile in triton x-100 induced hyperlipidemia in rats. Kafr El-Sheikh Veterinary Medical Journal،Vol. 12, no. 2, pp.109-127.
https://search.emarefa.net/detail/BIM-761562
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Taha, Nabil…[et al.]. Effect of garlic and atorvastatin on leptin and lipid profile in triton x-100 induced hyperlipidemia in rats. Kafr El-Sheikh Veterinary Medical Journal Vol. 12, no. 2 (2014), pp.109-127.
https://search.emarefa.net/detail/BIM-761562
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Taha, Nabil& Abd al-Hamid, Hatim S.& Sadiq, Qadri M.& Abd al-Aziz, Ahmad Z.. Effect of garlic and atorvastatin on leptin and lipid profile in triton x-100 induced hyperlipidemia in rats. Kafr El-Sheikh Veterinary Medical Journal. 2014. Vol. 12, no. 2, pp.109-127.
https://search.emarefa.net/detail/BIM-761562
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 123-127
رقم السجل
BIM-761562
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر