Effect of garlic and atorvastatin on leptin and lipid profile in triton x-100 induced hyperlipidemia in rats
Joint Authors
Abd al-Hamid, Hatim S.
Sadiq, Qadri M.
Abd al-Aziz, Ahmad Z.
Taha, Nabil
Source
Kafr El-Sheikh Veterinary Medical Journal
Issue
Vol. 12, Issue 2 (31 Dec. 2014), pp.109-127, 19 p.
Publisher
Kafr El-Sheikh University Faculty of Veterinary Medicine
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Topics
Abstract EN
Hyperlipidemia is widely known to be the major risk factor for the development of cardiovascular diseases.
This study was conducted to determine the effect of Garlic on Leptin hormone and Lipid Profile in Triton x-100 induced hyperlipidemic rats compared with standard hypolipidemic Atorvasta in.
A total number of 60 albino rats were allocated into six equal groups, 10 rats each.
The first group was kept on Standard pellet diet (served as normal control), the second group was kept on 1% garlic added to standard pellet diet, the third group was administered with standard Atorvastatin 10 mg/kg p.o.
daily (served as standard), the forth group was given a single dose of triton at a dose 100 mg/kg and repeated every two weeks, i.p.
(served as Triton control), fifth and sixth groups were given a single dose of triton at a dose 100 mg/kg and repeated every two weeks, i.p.
and the fifth group was given arlic 1% added to standard pellet diet while sixth group was administered with standard Atorvastatin 10 mg/kg p.o.
(served as treated groups), after inducing hyperlipidemia (for 6 weeks).
Results showed that, garlic significantly decreased cholesterol, LDL-C, VLDL-C and TG and significantly increased HDL compared with triton x-100 -treated group.
On the other hand, there were a non significant differences in total lipid, phospholipids and leptin levels compared with triton x-100 -treated group.
We concluded that, Garlic has definite antihyperlipidemic activity in Triton X-100 induced hyperlipidemia model which is equipotent activity when compared with Atorvastatin.
This might returned in addition to its own hypolipidemc activity to increased leptin sensitivity in hypothalamus.
Further studies on Garlic needed to identify the possible mechanism of action on leptin hormone.
American Psychological Association (APA)
Taha, Nabil& Abd al-Hamid, Hatim S.& Sadiq, Qadri M.& Abd al-Aziz, Ahmad Z.. 2014. Effect of garlic and atorvastatin on leptin and lipid profile in triton x-100 induced hyperlipidemia in rats. Kafr El-Sheikh Veterinary Medical Journal،Vol. 12, no. 2, pp.109-127.
https://search.emarefa.net/detail/BIM-761562
Modern Language Association (MLA)
Taha, Nabil…[et al.]. Effect of garlic and atorvastatin on leptin and lipid profile in triton x-100 induced hyperlipidemia in rats. Kafr El-Sheikh Veterinary Medical Journal Vol. 12, no. 2 (2014), pp.109-127.
https://search.emarefa.net/detail/BIM-761562
American Medical Association (AMA)
Taha, Nabil& Abd al-Hamid, Hatim S.& Sadiq, Qadri M.& Abd al-Aziz, Ahmad Z.. Effect of garlic and atorvastatin on leptin and lipid profile in triton x-100 induced hyperlipidemia in rats. Kafr El-Sheikh Veterinary Medical Journal. 2014. Vol. 12, no. 2, pp.109-127.
https://search.emarefa.net/detail/BIM-761562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 123-127
Record ID
BIM-761562