Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target
المؤلفون المشاركون
Yang, Feng
Chen, Chuanliang
Tian, Tongde
Tang, Jingwen
Pei, Junwen
Shi, Bian
Zhang, Jianhua
Zhang, Ning
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 24، العدد 3 (31 مارس/آذار 2017)، ص ص. 634-643، 10ص.
الناشر
تاريخ النشر
2017-03-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
The paper aimed to screen out genetic markers applicable to early diagnosis for colorectal cancer and establish apoptotic regulatory network model for colorectal cancer, and to analyze the current situation of traditional Chinese medicine (TCM) target, thereby providing theoretical evidence for early diagnosis and targeted therapy of colorectal cancer.
Taking databases including CNKI, VIP, Wanfang data, Pub Med, and MEDLINE as main sources of literature retrieval, literatures associated with genetic markers that are applied to early diagnosis of colorectal cancer were searched and performed comprehensive and quantitative analysis by Meta analysis, hence screening genetic markers used in early diagnosis of colorectal cancer.
KEGG analysis was employed to establish apoptotic regulatory network model based on screened genetic markers, and optimization was conducted on TCM targets.
Through Meta analysis, seven genetic markers were screened out, including WWOX, K-ras, COX-2, P53, APC, DCC and PTEN, among which DCC has the highest diagnostic efficiency.
Apoptotic regulatory network was built by KEGG analysis.
Currently, it was reported that TCM has regulatory function on gene locus in apoptotic regulatory network.
The apoptotic regulatory model of colorectal cancer established in this study provides theoretical evidence for early diagnosis and TCM targeted therapy of colorectal cancer in clinic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Tongde& Chen, Chuanliang& Yang, Feng& Tang, Jingwen& Pei, Junwen& Shi, Bian…[et al.]. 2017. Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target. Saudi Journal of Biological Sciences،Vol. 24, no. 3, pp.634-643.
https://search.emarefa.net/detail/BIM-761773
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Tongde…[et al.]. Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target. Saudi Journal of Biological Sciences Vol. 24, no. 3 (Mar. 2017), pp.634-643.
https://search.emarefa.net/detail/BIM-761773
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Tongde& Chen, Chuanliang& Yang, Feng& Tang, Jingwen& Pei, Junwen& Shi, Bian…[et al.]. Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 3, pp.634-643.
https://search.emarefa.net/detail/BIM-761773
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 642-643
رقم السجل
BIM-761773
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر