Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target
Joint Authors
Yang, Feng
Chen, Chuanliang
Tian, Tongde
Tang, Jingwen
Pei, Junwen
Shi, Bian
Zhang, Jianhua
Zhang, Ning
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 3 (31 Mar. 2017), pp.634-643, 10 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
The paper aimed to screen out genetic markers applicable to early diagnosis for colorectal cancer and establish apoptotic regulatory network model for colorectal cancer, and to analyze the current situation of traditional Chinese medicine (TCM) target, thereby providing theoretical evidence for early diagnosis and targeted therapy of colorectal cancer.
Taking databases including CNKI, VIP, Wanfang data, Pub Med, and MEDLINE as main sources of literature retrieval, literatures associated with genetic markers that are applied to early diagnosis of colorectal cancer were searched and performed comprehensive and quantitative analysis by Meta analysis, hence screening genetic markers used in early diagnosis of colorectal cancer.
KEGG analysis was employed to establish apoptotic regulatory network model based on screened genetic markers, and optimization was conducted on TCM targets.
Through Meta analysis, seven genetic markers were screened out, including WWOX, K-ras, COX-2, P53, APC, DCC and PTEN, among which DCC has the highest diagnostic efficiency.
Apoptotic regulatory network was built by KEGG analysis.
Currently, it was reported that TCM has regulatory function on gene locus in apoptotic regulatory network.
The apoptotic regulatory model of colorectal cancer established in this study provides theoretical evidence for early diagnosis and TCM targeted therapy of colorectal cancer in clinic.
American Psychological Association (APA)
Tian, Tongde& Chen, Chuanliang& Yang, Feng& Tang, Jingwen& Pei, Junwen& Shi, Bian…[et al.]. 2017. Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target. Saudi Journal of Biological Sciences،Vol. 24, no. 3, pp.634-643.
https://search.emarefa.net/detail/BIM-761773
Modern Language Association (MLA)
Tian, Tongde…[et al.]. Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target. Saudi Journal of Biological Sciences Vol. 24, no. 3 (Mar. 2017), pp.634-643.
https://search.emarefa.net/detail/BIM-761773
American Medical Association (AMA)
Tian, Tongde& Chen, Chuanliang& Yang, Feng& Tang, Jingwen& Pei, Junwen& Shi, Bian…[et al.]. Establishment of apoptotic regulatory network for genetic markers of colorectal cancer and optimal selection of traditional Chinese medicine target. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 3, pp.634-643.
https://search.emarefa.net/detail/BIM-761773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 642-643
Record ID
BIM-761773