Evaluation of in vitro production of cytokines by monocytes-macrophages in patients with heart failure

الملخص EN

Abstract Recent studies showed an important role of inflammation in heart failure (HF).

Monocytes/macrophages are main cells in immune response.

The aim was to investigate spontaneous cytokines production by monocytes/ macrophages in patient with ischemic heart failure.

Methods Ninety six patients with HF of ischemic genesis were observed.

The spontaneous production of interleukin 1 (IL-1), interleukin 6 (IL-6), and interleukin 10 (IL-10) by monocytes/macrophages in vitro was detected by ELISA method.

Results The in vitro spontaneous production of pro inflammatory cytokines IL-1 and IL-6 by monocytes/ macrophages in patients with HF was significant higher and antiinflammatory IL-10 was lower than in control group.

The progression of HF caused to increase of spontaneous production by monocytes/ macrophages of IL-1 and IL-6 but decrease of IL-10.

Conclusion The monocytes/macrophages in patients with ischemic HF are in condition of chronic activation which manifests of overproduction of pro inflammatory cytokines and poor secretion of anti-inflammatory IL-10.