Evaluation of in vitro production of cytokines by monocytes-macrophages in patients with heart failure
Other Title(s)
الإنتاج التلقائي للسيتوكينات الالتهابية و المضادة للالتهاب من الخلايا الوحيدة-البالعة عند مرضى قصور القلب
Joint Authors
Fedorov, Sergiy
Glushko, Liubomyr
Frankivsk, Ivano
Source
Issue
Vol. 8, Issue 2 (31 Dec. 2014), pp.78-84, 7 p.
Publisher
University of Duhok College of Medicine
Publication Date
2014-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Abstract Recent studies showed an important role of inflammation in heart failure (HF).
Monocytes/macrophages are main cells in immune response.
The aim was to investigate spontaneous cytokines production by monocytes/ macrophages in patient with ischemic heart failure.
Methods Ninety six patients with HF of ischemic genesis were observed.
The spontaneous production of interleukin 1 (IL-1), interleukin 6 (IL-6), and interleukin 10 (IL-10) by monocytes/macrophages in vitro was detected by ELISA method.
Results The in vitro spontaneous production of pro inflammatory cytokines IL-1 and IL-6 by monocytes/ macrophages in patients with HF was significant higher and antiinflammatory IL-10 was lower than in control group.
The progression of HF caused to increase of spontaneous production by monocytes/ macrophages of IL-1 and IL-6 but decrease of IL-10.
Conclusion The monocytes/macrophages in patients with ischemic HF are in condition of chronic activation which manifests of overproduction of pro inflammatory cytokines and poor secretion of anti-inflammatory IL-10.
American Psychological Association (APA)
Fedorov, Sergiy& Glushko, Liubomyr& Frankivsk, Ivano. 2014. Evaluation of in vitro production of cytokines by monocytes-macrophages in patients with heart failure. Duhok Medical Journal،Vol. 8, no. 2, pp.78-84.
https://search.emarefa.net/detail/BIM-763666
Modern Language Association (MLA)
Fedorov, Sergiy…[et al.]. Evaluation of in vitro production of cytokines by monocytes-macrophages in patients with heart failure. Duhok Medical Journal Vol. 8, no. 2 (Dec. 2014), pp.78-84.
https://search.emarefa.net/detail/BIM-763666
American Medical Association (AMA)
Fedorov, Sergiy& Glushko, Liubomyr& Frankivsk, Ivano. Evaluation of in vitro production of cytokines by monocytes-macrophages in patients with heart failure. Duhok Medical Journal. 2014. Vol. 8, no. 2, pp.78-84.
https://search.emarefa.net/detail/BIM-763666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 81-82
Record ID
BIM-763666