Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats

المؤلف

Zargar, Seema

المصدر

Saudi Journal of Biological Sciences

العدد

المجلد 21، العدد 2 (30 إبريل/نيسان 2014)، ص ص. 139-145، 7ص.

الناشر

الجمعية السعودية لعلوم الحياة

تاريخ النشر

2014-04-30

دولة النشر

السعودية

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Trigonella foenum-graecum belongs to the family Fabaceae and is indigenous to countries that lie on the eastern shores of the Mediterranean Sea and is also cultivated in India, Egypt and Africa.

This study provides the evidence indicating the therapeutic effect of the extract prepared from the dried seeds of Trigonella foenum-graecum on an animal model of hepatotoxicity and on cell proliferation.

Rats were induced liver cirrhosis by thioacetamide (0.03% in water for 16 weeks).

Transmission electron microscopy of the liver tissue was done to evaluate liver cirrhosis.

The herbal extract was administered orally for 3 weeks after induction and biochemical estimations were done.

After the administration of extract the oxidative stress and lipid peroxidation were reversed.

The elevated levels of alkaline phosphatase, c-glutamyl transferase and selected biochemical markers of liver cirrhosis including drug metabolizing enzymes were also reversed.

The study has implications in finding a treatment for liver cirrhosis by a natural herbal drug with no side effects

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zargar, Seema. 2014. Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi Journal of Biological Sciences،Vol. 21, no. 2, pp.139-145.
https://search.emarefa.net/detail/BIM-766985

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zargar, Seema. Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi Journal of Biological Sciences Vol. 21, no. 2 (Apr. 2014), pp.139-145.
https://search.emarefa.net/detail/BIM-766985

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zargar, Seema. Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi Journal of Biological Sciences. 2014. Vol. 21, no. 2, pp.139-145.
https://search.emarefa.net/detail/BIM-766985

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 144-145

رقم السجل

BIM-766985