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Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats
Author
Source
Saudi Journal of Biological Sciences
Issue
Vol. 21, Issue 2 (30 Apr. 2014), pp.139-145, 7 p.
Publisher
Publication Date
2014-04-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Trigonella foenum-graecum belongs to the family Fabaceae and is indigenous to countries that lie on the eastern shores of the Mediterranean Sea and is also cultivated in India, Egypt and Africa.
This study provides the evidence indicating the therapeutic effect of the extract prepared from the dried seeds of Trigonella foenum-graecum on an animal model of hepatotoxicity and on cell proliferation.
Rats were induced liver cirrhosis by thioacetamide (0.03% in water for 16 weeks).
Transmission electron microscopy of the liver tissue was done to evaluate liver cirrhosis.
The herbal extract was administered orally for 3 weeks after induction and biochemical estimations were done.
After the administration of extract the oxidative stress and lipid peroxidation were reversed.
The elevated levels of alkaline phosphatase, c-glutamyl transferase and selected biochemical markers of liver cirrhosis including drug metabolizing enzymes were also reversed.
The study has implications in finding a treatment for liver cirrhosis by a natural herbal drug with no side effects
American Psychological Association (APA)
Zargar, Seema. 2014. Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi Journal of Biological Sciences،Vol. 21, no. 2, pp.139-145.
https://search.emarefa.net/detail/BIM-766985
Modern Language Association (MLA)
Zargar, Seema. Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi Journal of Biological Sciences Vol. 21, no. 2 (Apr. 2014), pp.139-145.
https://search.emarefa.net/detail/BIM-766985
American Medical Association (AMA)
Zargar, Seema. Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi Journal of Biological Sciences. 2014. Vol. 21, no. 2, pp.139-145.
https://search.emarefa.net/detail/BIM-766985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 144-145
Record ID
BIM-766985