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Effect of fluorescein angiography on renal functions in type 2 diabetes patients : a pilot study
المؤلفون المشاركون
Abd al-Hadi, Ahmad M.
al-Maliki, Walid H.
Abd Allah, Ashraf Nabil
al-kirai, Ahmad F.
al-Rjjal, Mahmud
al-Rjjal, Muhammad E.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 28، العدد 3 (30 يونيو/حزيران 2017)، ص ص. 491-498، 8ص.
الناشر
تاريخ النشر
2017-06-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Fluorescein angiography (FA) is an important tool for the diagnosis and management of diabetic retinopathy.
However, the safety of fluorescein sodium on renal functions is not fully understood.
One hundred type 2 diabetes patients, within the Ophthalmology Outpatient Clinic at Alexandria Main University Hospital, Egypt, were enrolled in this prospective observational study to determine the safety of FA on renal function.
Serum creatinine and cystatin C were measured pre- and 2 days post-FA.
Urinary neutrophil gelatinase-associated lipocalin (uNGAL) was measured pre- and 4 hours post-FA.
Renal injury was defined as a 25% increase in serum creatinine, cystatin C, or uNGAL.
The study included 71 females and 29 males, with a mean age of 55.73 ± 7.29 years.
Baseline serum cystatin C and uNGAL were 0.89 ± 0.34 mg/L and 21.7 ± 2.39 ng/mL, respectively.
Serum cystatin C and uNGAL significantly increased after FA to 0.95 ± 0.36 and 27 ± 2.81, respectively (P <0.001).
Eleven patients (11%) experienced more than a 25% rise in serum cystatin C from baseline, whereas 40 patients (40%) experienced more than a 25% increase in uNGAL levels after FA.
However, the mean serum creatinine level did not change significantly after FA (P = 0.061).
Only one patient experienced more than a 25% rise in serum creatinine from baseline.
FA showed a significant increase in early sensitive acute kidney injury biomarkers (as serum cystatin C and uNGAL) in substantial number of patients, suggesting but still not proving, a potential harmful effect of FA on kidney functions.
These findings were not demonstrated using ordinary serum creatinine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Maliki, Walid H.& Abd Allah, Ashraf Nabil& al-kirai, Ahmad F.& Abd al-Hadi, Ahmad M.& al-Rjjal, Mahmud& al-Rjjal, Muhammad E.. 2017. Effect of fluorescein angiography on renal functions in type 2 diabetes patients : a pilot study. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 3, pp.491-498.
https://search.emarefa.net/detail/BIM-767409
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Maliki, Walid H.…[et al.]. Effect of fluorescein angiography on renal functions in type 2 diabetes patients : a pilot study. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 3 (May. / Jun. 2017), pp.491-498.
https://search.emarefa.net/detail/BIM-767409
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Maliki, Walid H.& Abd Allah, Ashraf Nabil& al-kirai, Ahmad F.& Abd al-Hadi, Ahmad M.& al-Rjjal, Mahmud& al-Rjjal, Muhammad E.. Effect of fluorescein angiography on renal functions in type 2 diabetes patients : a pilot study. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 3, pp.491-498.
https://search.emarefa.net/detail/BIM-767409
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 496-498
رقم السجل
BIM-767409
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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