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Effect of fluorescein angiography on renal functions in type 2 diabetes patients : a pilot study
Joint Authors
Abd al-Hadi, Ahmad M.
al-Maliki, Walid H.
Abd Allah, Ashraf Nabil
al-kirai, Ahmad F.
al-Rjjal, Mahmud
al-Rjjal, Muhammad E.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 3 (30 Jun. 2017), pp.491-498, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-06-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Fluorescein angiography (FA) is an important tool for the diagnosis and management of diabetic retinopathy.
However, the safety of fluorescein sodium on renal functions is not fully understood.
One hundred type 2 diabetes patients, within the Ophthalmology Outpatient Clinic at Alexandria Main University Hospital, Egypt, were enrolled in this prospective observational study to determine the safety of FA on renal function.
Serum creatinine and cystatin C were measured pre- and 2 days post-FA.
Urinary neutrophil gelatinase-associated lipocalin (uNGAL) was measured pre- and 4 hours post-FA.
Renal injury was defined as a 25% increase in serum creatinine, cystatin C, or uNGAL.
The study included 71 females and 29 males, with a mean age of 55.73 ± 7.29 years.
Baseline serum cystatin C and uNGAL were 0.89 ± 0.34 mg/L and 21.7 ± 2.39 ng/mL, respectively.
Serum cystatin C and uNGAL significantly increased after FA to 0.95 ± 0.36 and 27 ± 2.81, respectively (P <0.001).
Eleven patients (11%) experienced more than a 25% rise in serum cystatin C from baseline, whereas 40 patients (40%) experienced more than a 25% increase in uNGAL levels after FA.
However, the mean serum creatinine level did not change significantly after FA (P = 0.061).
Only one patient experienced more than a 25% rise in serum creatinine from baseline.
FA showed a significant increase in early sensitive acute kidney injury biomarkers (as serum cystatin C and uNGAL) in substantial number of patients, suggesting but still not proving, a potential harmful effect of FA on kidney functions.
These findings were not demonstrated using ordinary serum creatinine.
American Psychological Association (APA)
al-Maliki, Walid H.& Abd Allah, Ashraf Nabil& al-kirai, Ahmad F.& Abd al-Hadi, Ahmad M.& al-Rjjal, Mahmud& al-Rjjal, Muhammad E.. 2017. Effect of fluorescein angiography on renal functions in type 2 diabetes patients : a pilot study. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 3, pp.491-498.
https://search.emarefa.net/detail/BIM-767409
Modern Language Association (MLA)
al-Maliki, Walid H.…[et al.]. Effect of fluorescein angiography on renal functions in type 2 diabetes patients : a pilot study. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 3 (May. / Jun. 2017), pp.491-498.
https://search.emarefa.net/detail/BIM-767409
American Medical Association (AMA)
al-Maliki, Walid H.& Abd Allah, Ashraf Nabil& al-kirai, Ahmad F.& Abd al-Hadi, Ahmad M.& al-Rjjal, Mahmud& al-Rjjal, Muhammad E.. Effect of fluorescein angiography on renal functions in type 2 diabetes patients : a pilot study. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 3, pp.491-498.
https://search.emarefa.net/detail/BIM-767409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 496-498
Record ID
BIM-767409